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Editorial Board
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IFC
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Table of Contents
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Editorial Supplement Volume 13, Issue 3 Cardiovascular Pathology Welcomes XIII IVBM-2004
We are pleased to publish the abstracts of the XIII International Vascular Biology Meeting being held in Toronto, Canada from June 1 to 5th, 2004 at the Conference Center of the Westin Harbour Castle ...
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Avrum I. Gotlieb,
Jagdish Butany
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1-2
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PODOPLANIN GENE DEFICIENCY CAUSES LYMPHATIC MALFORMATION AND LYMPHOCYTE DEVELOPMENTAL DEFECTS
Lymphatic vessels are essential tissue for homeostasis, fat absorption and for immune surveillance. Podoplanin, a mucin-like membrane-bound glycoprotein, has been defined as a novel phenotypic marker ...
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Pavel Uhrin,
Jan Zaujec,
Miroslav Bauer,
Mario Hilpert,
Heinrich Kowalski,
Elke Furtbauer,
Martin Bilban,
Hannes Stockinger,
Dontscho Kerjaschki,
Bernd R Binder
et al.
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3
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RHOA-DEPENDENT NUCLEAR TRANSLOCATION OF MYOCARDIN RELATED TRANSCRIPTION FACTOR A IS IMPORTANT FOR SMC-SPECIFIC TRANSCRIPTION
We have previously shown that RhoA signaling regulates serum response factor (SRF)-dependent transcription of the smooth muscle cell (SMC)-specific genes. The recent observation that nuclear localizat...
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Jeremiah S Hinson,
Dionne Morris,
Kashelle Lockman,
Matthew D Medlin,
Joan M Taylor,
Christopher P Mack
et al.
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3
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OSTEOPROTEGERIN AN AVB3-INDUCED ENDOTHELIAL CELL SURVIVAL MOLECULE
Osteoprotegerin (OPG), a soluble member of the TNF-receptor superfamily, is known to regulate osteoclast differentiation, activation, and survival. We found that OPG expression was induced by avb3 lig...
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Marta Scatena,
Laura Pritzker,
Cecilia M Giachelli
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3-4
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HIGH DENSITY LIPOPROTEINS MODULATE REDOX STATUS OF THIOREDOXINS—PUTATIVE MECHANISM TO EXPLAIN THE DIFFERENTIAL EFFECTS ON MAPK ACTIVATION
High Density Lipoproteins (HDLs), delivered as a bolus during reperfusion following hypovolaemic shock, protect against the subsequent vascular damage and multiple organ failure. Since changes in shea...
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Mehul Dhinoja,
John Frangos,
Gillian Cockerill
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4
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NATIVE LDL OXIDATION IN RESPONSE TO PULSATILE FLOW: IMPLICATION FOR NADPH OXIDASE EXPRESSION
Shear stress, cyclic strain, and oxidized LDL, were reported to modulate endothelial NADPH oxidase expression. Both LDL- and LDL-2, the in vivo oxidatively modified LDL, are known to induce proinflamm...
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Joshua Bross,
Juliana Hwang,
Michael Ing,
Alex Sevanian,
Tzung Hsiai
et al.
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4
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DYNAMIC REMODELING OF ENDOTHELIAL ADHEREN JUNCTIONS IN RESPONSE TO LONG-TERM ADAPTATION TO ARTERIAL HEMODYNAMICS
Isolated endothelial cells (ECs) in culture lose regional and tissue specific traits. The absence of appropriate in vivo stimulation contribute to this loss, however, most in vitro models do not attem...
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Elizabeth Browning,
Andrew Pryor,
Brett Blackman
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4-5
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THE VASCULAR PROTEINS JAM-B AND JAM-C ARE INVOLVED IN REMODELING INTER-ENDOTHELIAL JUNCTIONS
The mechanisms regulating capillary tube formation are of importance for angiogenesis in development, inflammation and cancer. During angiogenesis, endothelial cells proliferate, migrate into new tiss...
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Chrystelle Lamagna,
Michel Aurrand-Lions,
Beat A Imhof
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5
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COEXISTING PRO-INFLAMMATORY AND ANTI-OXIDATIVE ENDOTHELIAL TRANSCRIPTION PROFILES IN A DISTURBED FLOW REGION OF THE ADULT PORCINE AORTA
In the arterial circulation, regions of disturbed flow (DF), characterized by flow separation and transient vortices, are susceptible to atherogenesis whereas regions of undisturbed laminar flow (UF) ...
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Anthony G Passerini,
Denise C Polacek,
Congzhu Shi,
Nadeene M Francesco,
Gary Y Chang,
Peter F Davies
et al.
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5
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CHARACTERIZATION OF Ath17, A QUANTITATIVE TRAIT LOCUS FOR ATHEROSCLEROSIS SUSCEPTIBILITY BETWEEN C57BL/6J AND 129S1/SvImJ; SINGLE-NUCLEOTIDE POLYMORPHISMS HAVE IMPORTANT IMPLICATIONS ON IDENTIFYING ATHEROSCLEROSIS MODIFIER GENES
Although identifying quantitative trait loci (QTL) for atherosclerosis susceptibility in experimental murine models has helped us better understand the pathophysiology of atherosclerosis, identifying ...
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Naoki Ishimori,
Kenneth Walsh,
Xiangqun Zheng,
Fu Lu,
Sridhar Hannenhalli,
Deborah Nusskern,
Richard Mural,
Beverly Paigen
et al.
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5-6
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RAPID UROKINASE RECEPTOR (UPAR) AND INTEGRIN REDISTRIBUTION DURING VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF)-INDUCED ENDOTHELIAL CELL MIGRATION: REGULATION BY PRO-UROKINASE (PRO-UPA) ACTIVATION AND UPAR INTERNALIZATION
We could show previously that stimulation of human endothelial cells by VEGFR-2 rapidly induces a change in beta-1 integrin affinity, leading to MMP-2 and MT1-MMP dependent pro-uPA activation and subs...
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Johannes Breuss,
Gerald W Prager,
Stefan Steurer,
Damla Olcaydu,
Patrick Brunner,
Judit Mihaly,
Alexandra Kadl,
Bernd R Binder
et al.
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6
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PAXILLIN SELECTIVELY ASSOCIATES WITH HIGH AFFINITY α4β1 INTEGRINS: IMPLICATIONS FOR INTEGRIN SIGNALING
α4 integrins are expressed on mononuclear leukocytes and mediate adhesion to vascular cell adhesion molecule-1 (VCAM-1) and the CS-1 fragment of fibronectin. VCAM-1 is expressed by vascular endotheliu...
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Sharon J Hyduk,
Haiyan Xiao,
Myron I Cybulsky
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6
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INTEGRIN-LINKED KINASE EXPRESSION MODULATES INTIMAL THICKENING BY REGULATING VASCULAR SMOOTH MUSCLE GROWTH AND MIGRATION
Proliferation and migration of vascular smooth muscle cell (VSMC) plays a key role in the development of pathological process characterized by intimal thickening, such as atherosclerosis and restenosi...
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mrita Dwivedi,
Graciela B Sala-Newby,
Andrew C Newby,
Sarah J George
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6-7
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QUAKING REGULATION OF VISCERAL ENDODERM FUNCTION IS REQUIRED FOR VASCULAR REMODELING AND RETINOIC ACID-MEDIATED CONTROL OF ENDOTHELIAL CELL PROLIFERATION
The ENU-induced point mutation in the RNA binding domain of quaking (qk) yields embryonic lethal defects in blood vessel assembly and remodeling despite normal cardiac muscle differentiation and funct...
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Brenda L Bohnsack,
Lihua Lai,
Irene Patniyot,
Trevor Crowell,
Jennifer L Northrop,
Monica J Justice,
Karen K Hirschi
et al.
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7
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VCAM-1 ACTIVATION OF ENDOTHELIAL CELL MMP-2 AND MMP-9: ROLE OF REACTIVE OXYGEN SPECIES
Endothelial cells generate reactive oxygen species (ROS) that can regulate infiltration of lymphocytes into tissues. Endothelial cell attachment of lymphocytes is mediated by adhesion molecules such a...
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Joan Cook-Mills,
Tracy Deem
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7
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ALPHA M AND ALPHA X BETA2 INTEGRINS CO-OPERATE TO MEDIATE MONOCYTE ADHESION TO PLATELETS UNDER FLOW
Leukocyte interaction with platelets at sites of vascular injury, have been found to play a critical role in the inflammatory responses associated with ischemia-reperfusion injury and post-angioplasty...
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Varuni Kanagasundaram,
Thanae Georgakopoulos,
Suhasini Kulkarni,
Warwick Nesbitt,
Hatem H Salem,
Shaun P Jackson
et al.
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7-8
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VASP EXPRESSION RETARDS VASCULAR SMOOTH MUSCLE MIGRATION
Vasodilator-stimulated phosphoprotein (VASP) is a focal adhesion protein involved in the regulation of the cellular cytoskeleton through the promotion, bundling and nucleation of elongated actin filam...
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Kanchan Chitaley,
Lihua Chen,
Guenter Daum,
Alexander W Clowes
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8
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AKT/PKB REGULATES MICROVASCULAR REMODELING AND HOMEOSTASIS
In microvascular development, newly formed vessels undergo extensive morphological remodeling to establish the final microvessel pattern. Studies of microvascular remodeling in the retina under hypero...
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Thuy Phung,
Jing Fang Sun,
Terri Felske,
Ichiro Shiojima,
Ann Dvorak,
Janice Nagy,
Kenneth Walsh,
Harold Dvorak,
Laura Benjamin
et al.
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8
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E-SELECTIN IS REQUIRED FOR THE ANTI-ANGIOGENIC ACTIVITY OF ENDOSTATIN
Endostatin, a 20 kDa fragment of collagen XVIII, is a potent angiogenesis inhibitor. E-selectin, an inducible leukocyte adhesion molecule specifically expressed by endothelial cells, has also been imp...
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Ying Yu,
Karen Moulton,
Mohamed Khan,
Sabrina Vineberg,
Eileen Boye,
Vannessa Davis,
Peter O'Donnell,
Joyce Bischoff,
David Milstone
et al.
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8-9
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THE ROLE OF CHOLESTEROL HOMEOSTASIS REGULATORY PROTEINS, CAVEOLIN AND SREBP, IN CHEMOKINE INDUCTION BY PHOSPHOLIPID OXIDATION PRODUCT
In this study we report a novel signaling pathway responsible for induction of endothelial cytokine synthesis by oxidized phospholipid (Ox-PAPC) involving a change in caveolar cholesterol content. It ...
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Michael Yeh,
Amy L Cole,
Jenny Choi,
Jian-Hua Qiao,
Michael Fishbein,
Judith A Berliner
et al.
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9-10
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PROTEOLYTIC PROCESSING OF VEGF-A AFFECTS BIOLOGICAL ACTIVITY WITHOUT ALTERING VEGFR-2 PHOSPHORYLATION LEVELS
VEGF-A is one of the most relevant mediators of capillary morphogenesis during development and a key stimulator of tumor-induced angiogenesis. Targeted gene inactivation studies indicated minimal tole...
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Sunyoung Lee,
Shahla Jilani,
Ganka V. Nikolova,
Darren Carpizo,
Erin Yokoyama,
M.Luisa Iruela-Arispe
et al.
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9
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HUMAN ALLOGENEIC T CELL-MEDIATED VASCULAR DYSFUNCTION DEPENDS ON INTERFERON-GAMMA
Impaired vascular reactivity (dysfunction) frequently develops in the conduit arteries of vascularized organ grafts as an early sign of vascular rejection. Here we demonstrate that allogeneic T lympho...
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Kian Peng Koh,
Yinong Wang,
Tai Yi,
Marc I Lorber,
William C Sessa,
George Tellides,
Jordan S Pober
et al.
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9
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DECIPHERING THE HISTONE CODE OF THE E-SELECTIN GENE: CHROMATIN ARCHITECTURE & INSIGHTS INTO ENDOTHELIAL-SPECIFIC GENE EXPRESSION
E-selectin plays a role in the binding and extravasation of leukocytes from the bloodstream. The E-selectin gene is rapidly and transiently expressed by endothelial cells activated by inflammatory sti...
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Leonard Edelstein,
Tucker Collins
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10
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POSITIVE AND NEGATIVE REGULATION OF THE CARDIOVASCULAR TRANSCRIPTION FACTOR KLF5 BY THE COACTIVATOR/ACETYLASE P300 AND THE ONCOGENIC REGULATOR/NUCLEOSOME ASSEMBLY FACTOR SET BY INTERACTION AND ACETYLATION—IMPLICATIONS FOR TRANSCRIPTIONAL REGULATION OF GENE EXPRESSION AT THE CHROMATIN LEVEL
Background: The mechanisms underlying specific transcriptional regulation at the level of chromatin/nucleosome DNA are unclear. An important question which remains unanswered is how transcriptional co...
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Toru Suzuki,
Saku Miyamoto,
Shinsuke Muto,
Kenichi Aizawa,
Masami Horikoshi,
Ryozo Nagai
et al.
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10
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TISSUE-ENGINEERED MICROVESSELS ON THREE-DIMENSIONAL BIODEGRADABLE POLYMER SCAFFOLDS USING HUMAN ENDOTHELIAL PROGENITOR CELLS
Tissue-engineered (TE) organs and tissues will require a microvascular network to supply oxygen and nutrients. One strategy for creating a microvasculature would be to promote vasculogenesis in situ b...
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Xiao Wu,
Elena Rabkin,
Kristine J Guleserian,
Tjorvi E Perry,
Yutaka Masuda,
Fraser W.H Sutherland,
Frederick J Schoen,
John E Mayer,
Joyce Bischoff
et al.
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10-11
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MYO/ENDOTHELIAL DIFFERENTIATION OF HUMAN UMBILICAL CORD BLOOD-DERIVED STEM CELLS IN ISCHEMIC LIMB TISSUES
We have recently found that human cord blood CD34+ EPCs give rise to endothelial and skeletal muscle cells in vitro and in a mouse model of hind limb ischemia (Pesce et al Circ Res. 2003;93:e51–e62). ...
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Alessia Orlandi,
Maria Grazia Iachininoto,
Anna Rita Torella,
Antonella Zacheo,
Anna di Carlo,
Giuseppina Bonanno,
Giovanni Scambia,
Giulio Pompilio,
Maurizio C Capogrossi,
Maurizio Pesce
et al.
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11
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ROLE OF ENDOTHELIN-1 IN ACCELERATED ATHEROSCLEROSIS AND ANEURYSM FORMATION INDUCED BY ANGIOTENSIN II
Chronic administration of Angiotensin II (AII) leads to accelerated atherosclerosis and aneurysm formation in apolipoprotein E-deficient (apoE−/−) mice. Endothelin-1 (ET-1) has also been implicated in...
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Rene S Suen,
Duncan J Stewart
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11
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SALT-SENSITIVE AND PREGNANCY-INDUCED HYPERTENSION IN MICE DEFICIENT IN CORIN, THE PRO-ATRIAL NATRIURETIC PEPTIDE CONVERTASE
Corin is a recently identified transmembrane serine protease expressed primarily in cardiomyocytes. In vitro, it converts pro-atrial natriuretic peptide (pro-ANP) to mature ANP, suggesting that it is ...
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Joyce Chan,
Ole Knudson,
John Morser,
William Dole,
Qingyu Wu
et al.
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11-12
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MECHANISMS OF SMOOTH MUSCLE CELL-RESTRICTED GENE EXPRESSION
Consistent with the diverse embryonic origins of smooth muscle cells a number of studies have suggested that regulation of the expression of genes in different smooth muscle tissues is likely to be co...
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Paul Herring,
Ketrija Touw,
April Hoggatt,
Julia Azriel,
Omar El-Mounayri,
Jiliang Zhou,
Feng Yin
et al.
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12
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A NOVEL CROSSTALK BETWEEN PROTEASOMAL PROTEIN DEGRADATION AND SRF-DEPENDENT GENE TRANSCRIPTION IN VASCULAR SMOOTH MUSCLE CELLS
Vascular smooth muscle cells (VSMC) exist in two phenotypes: proliferative and contractile. The contractile phenotype is characterized by increased levels of smooth muscle (SM) cytoskeletal proteins. ...
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Nathan Sandbo,
Kyle Hogarth,
Yimin Qin,
Jason Elinoff,
Nickolai Dulin
et al.
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12
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ROLE OF TRANSGLUTAMINASE IN INWARD REMODELING OF SMALL CORONARY ARTERIES
Vascular remodeling results in a change in inner diameter under fully dilated conditions. This may occur without apparent changes in the amount of cellular and extracellular wall constituents. We hypo...
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Erik NTP Bakker,
Jop Perree,
Anuradha Ganga,
Oana Sorop,
Jos AE Spaan,
Ed VanBavel
et al.
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12-13
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GAP JUNCTION TRANSMITTED CALCIUM WAVES ARE INHIBITED BY NO: A SPECIFIC ROLE FOR CX37
The increase of intracellular Ca2+ concentration in response to bradykinin and other stimuli occurs initially only in a small fraction of an endothelial cell (EC) monolayer. These cells give then rise...
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Ulrich Pohl,
Petra Kameritsch
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13
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THE ROLE OF VEGFR2 AND TIE1 IN VASCULAR RESTRUCTURING MEDIATED BY SHEAR STRESS CHANGES
The endothelium lining the inner surface of blood vessels, experiences shear forces exerted by the flow of blood, which vary in magnitude and pattern and depend on flow velocity and vessel geometry. S...
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Nitzan Resnick,
Limor Chen-Konak,
Michal Zilberman,
Hava Yahav,
Ofer Binah,
Ayelet Salit-Shay
et al.
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13
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SHEAR STRESS-MEDIATED CHROMATIN REMODELING PROVIDES MOLECULAR BASIS FOR FLOW-DEPENDENT REGULATION OF GENE EXPRESSION
Shear stress (SS), the tangential component of hemodynamic forces, modulates the expression of several genes in endothelial cells. However, no information are available about its effect on chromatin s...
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Barbara Illi,
Simona Nanni,
Alessandro Scopece,
Antonella Farsetti,
Maurizio C Capogrossi,
Carlo Gaetano
et al.
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13-14
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SUBCELLULAR IMAGING OF ENDOTHELIAL MECHANOCHEMICAL DYNAMICS
Endothelial regulation of vascular wall biology depends on both mechanical and biochemical stimuli in a local region of the vessel wall. Endothelial cell behavior emerges from complex interactions amo...
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Brian P Helmke,
Colin K Choi,
Rosalind E Mott
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14
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NON-INVASIVE IMAGING OF INFLAMMATION IN HUMAN ATHEROSCLEROSIS USING 18-FLURODEOXYGLUCOSE POSITRON EMISSION TOMOGRAPHY AND HIGH RESOLUTION MAGNETIC RESONANCE
Inflammatory cells, particularly macrophages, weaken the fibrous cap of atherosclerotic lesions causing plaque rupture and subsequent clinical events such as stroke. Contrast angiography provides no i...
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John Davies,
James Rudd,
Timothy Fryer,
Elizabeth Warburton,
Rikin Trivedi,
Jonathan Gillard,
Peter Weissberg
et al.
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14
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NITRIC OXIDE MODULATES MURINE YOLK SAC VASCULOGENESIS AND RESCUES HIGH GLUCOSE INDUCED VASCULOPATHY
Several reproductive tissues, including the ovary, fallopian tubes and uterus, express nitric oxide synthase (NOS) isoforms. In the female reproductive tract, nitric oxide (NO) has been demonstrated t...
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Anjali Nath,
Josephine Enciso,
Misako Kuniyasu,
Xiao-Ying Hao,
Joseph A Madri,
Emese Pinter
et al.
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14-15
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CHANGES IN EXPRESSION OF THE SHEAR STRESS RESPONSIVE GENES KLF-2, ET-1 AND NOS-3 AFTER DISTURBING THE VENOUS RETURN IN CHICKEN EMBRYOS
Hemodynamics play an important role in cardiovascular development and changes in blood flow can cause congenital heart malformations. Shear stress, which is positively correlated to flow, is also impo...
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Bianca C.W Groenendijk,
Beerend P Hierck,
Adriana C Gittenberger-de Groot,
Robert E Poelmann
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15
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INACTIVATION OF VITAMIN D RECEPTOR SUPPRESSES DEVELOPMENT OF ATHEROSCLEROTIC CALCIFICATION IN APOE-DEFICIENT MICE
Vascular calcification is a common finding in atherosclerosis and has important clinical implications. This process may involve chondrogenic and/or osteogenic differentiation of vascular cells and be ...
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Atsushi Shioi,
Akane Kizu,
Shuichi Jono,
Hidenori Koyama,
Yasuhisa Okuno,
Shigeaki Kato,
Yoshiki Nishizawa
et al.
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15
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ALTERED VASCULAR REMODELING IN OSTEOPONTIN DEFICIENT ATHEROSCLEROTIC MICE
Osteopontin (OPN) is a cell-binding phosphoprotein with proposed functions in atherosclerosis. The aim of this study was to examine how OPN deficiency affects the atherosclerotic process.
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Asa Strom,
Ahnders Franzén,
Christel Wangnerud,
Ann-Katrin Knutsson,
Dick Heinegard,
Anna Hultgardh-Nilsson
et al.
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15
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MIDKINE (MK) CAUSES PULMONARY VASCULAR REMODELING AND IS RESPONSIVE TO HYPOXIA VIA HIF-1α
Midkine (MK), a 13-kDa heparin-binding growth factor, has been proposed to mediate various developmental processes, including angiogenesis, cell migration, and proliferation in various tissues includi...
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Paul R Reynolds,
Michae L Mucenski,
Jeffre A Whitsett
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15-16
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COMPENSATORY VASCULAR REMODELING DURING ATHEROSCLEROTIC LESION GROWTH DEPENDS ON MATRIX METALLOPROTEINASE-9 ACTIVITY
Compensatory vascular remodeling, defined as a permanent increase in blood vessel diameter, provides a mechanism for maintaining lumen patency in the face of atherosclerotic lesion growth. Matrix meta...
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Susan M Lessner,
Deborah E Martinson,
Zorina S Galis
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16
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MORPHOLOGIC REACTION PATTERNS TO AORTIC STENT GRAFT INCORPORATION
Over the past decade endovascular aortic stent grafts have become a useful alternative to open surgery for a selected group of patients. However, there is still little information available regarding ...
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Elisabeth Harrer,
Peter Grewe,
Thorben Ick,
Klaus-Michael Müller
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17
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CHARACTERIZATION OF ANEURYSMS IN A HYPOMORPHIC PKD1-MOUSE MODEL
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a multisystem disorder characterized by bilateral progressive cysts formation in kidneys. Serious complications of this disease are intracranial...
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Sabrin Hassane,
Irma S Lantinga-van Leeuwen,
J.Conny Van Munsteren,
Wouter Leonhard,
Nanna Claij,
Martijn H Breuning,
Adriana C Gittenberger-de Groot,
Dorien J.M Peters,
Marco C DeRuiter
et al.
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17
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INFLUENCE OF INTRALUMINAL THROMBUS ON STRUCTURAL FEATURES AND GENE EXPRESSION OF THE ANEURYSM WALL
It has been suggested that the intraluminal thrombus of abdominal aortic aneurysms (AAA) affects the underlying vessel wall. Aneurysm enlargement has been associated with growth of the thrombus and ru...
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Monsur Kazi,
Joy Roy,
Hanna Björk,
Chaoyong Zhu,
Anders Hamsten,
Jesper Swedenborg,
Ulf Hedin,
Per Eriksson
et al.
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17-18
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COLONIC MUCOSA IS A SOURCE OF INTERLEUKIN-6 PRODUCTION FOLLOWING ISCHAEMIA-REPERFUSION INJURY
Multiple organ dysfunction syndrome (MODS) is a cause of significant morbidity and mortality in the critically ill patient. Ischaemia-reperfusion (I-R) of the gut is postulated as being causally assoc...
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Nadeem Khwaja,
Jonathan Ghosh,
Victoria Howarth,
David Murray,
Raymond McMahon,
Paul Brenchley,
Jane Eddleston,
Michael Walker
et al.
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18
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ABDOMINAL AORTIC ANEURYSMS: A NOVEL EX VIVO CELL CULTURE METHOD TO ANALYSE INFLAMMATORY AND ANGIOGENIC PATHWAYS
Abdominal aortic aneurysms (AAA) occur in 5% men over 65 and aneurysm rupture causes 3% of sudden deaths in this population. AAA are the result of inflammation and proteolysis of the aortic wall, caus...
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Alexandra Kovalic,
Claudia Monaco,
Roger M Greenhalgh,
Ian J Franklin,
Ewa M Paleolog
et al.
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18
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ASCENDING AORTIC ANEURYSMS EXHIBIT INCREASED EXPRESSION OF CD68 AND MATRIX METALLOPROTEINASE-9
Most thoracic aortic aneurysms are associated with idiopathic, nonspecific medial degenerative disease. In light of increasing evidence that inflammation and over-expression of matrix metalloproteinas...
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Scott LeMaire,
Jonathan Wilks,
Xinwen Wang,
Stacey Carter,
Shixiang Wen,
Lori Conklin,
XingLi Wang,
Joseph Coselli
et al.
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18-19
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VASCULAR SMOOTH MUSCLE CELL AND SKIN FIBROBLAST PROPERTIES IN AORTIC ANEURYSM ASSOCIATED WITH BICUSPID AORTIC VALVE OR MARFAN SYNDROME: IDENTIFICATION OF LOCALISED VERSUS SYSTEMIC ABNORMALITIES
We have previously reported increased apoptosis and altered fibrillin, fibronectin and tenascin secretion and/or deposition in cultured vascular smooth muscle cells (VSMC) derived from aortic aneurysm...
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Maria Nataatmadja,
Malcolm West,
Caroline Millar,
Jennifer West,
Kim Summers,
Philip Walker
et al.
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19
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INVESTIGATING PROTEASE IMBALANCE IN ASCENDING AORTIC ANEURYSMS: WHAT IS THE OPTIMAL CONTROL?
Recent studies have suggested that matrix metalloproteinases (MMPs) are involved in the progression of thoracic aortic aneurysms and dissections. Samples of ascending aorta obtained during coronary ar...
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Jonathan Wilks,
Joseph Coselli,
Xinwen Wang,
Stacey Carter,
Shixiang Wen,
Dominic Leonardelli,
Gobind Anand,
Lori Conklin,
Matthias Loebe,
Scott LeMaire
et al.
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19
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CULTURED HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS IMPLANTED IN IMMUNODEFICIENT MICE CAN ACQUIRE ARTERIOLAR, CAPILLARY, AND VENULAR FEATURES
Human umbilical vein endothelial cells (HUVEC) suspended in collagen/fibronectin gels and implanted subcutaneously into CB-17 SCID/beige mice form a tubular network which inosculates with the mouse mi...
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David Enis,
Yinong Wang,
Michael Kashgarian,
Jeffrey Schechner,
Jordan Pober
et al.
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19-20
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IL-3 INDUCES EXPRESSION OF LYMPHATIC PHENOTYPIC MARKERS
Factors determining lymphatic differentiation in the adult organism are yet not well characterized. We have made the observation that mixed primary cultures of blood (BEC) and lymphatic (LEC) endothel...
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Marion Gröger,
Robert Loewe,
Wolfgang Holnthoner,
Robert Embacher,
Manuela Pillinger,
G.Scott Herron,
Klaus Wolff,
Peter Petzelbauer
et al.
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20
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PROTEOLYTIC ACTIVATION OF VEGF-C AND VEGF-D
The vascular endothelial growth factor (VEGF) family of proteins are secreted dimeric glycoproteins responsible for inducing angiogenesis and lymphangiogenesis. Binding to receptors occurs via sites l...
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Bradley McColl,
Megan Baldwin,
Sally Roufail,
Kari Alitalo,
Steven Stacker,
Marc Achen
et al.
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20
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CHARACTERIZATION OF ARTERIAL AND VENOUS ENDOTHELIAL CELLS DERIVED FROM HUMAN FULL TERM PLACENTA
In contrast to the well established knowledge about the heterogeneity between macro- and microvascular endothelial cells, only little is known about the morphological and functional heterogeneity of a...
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Ingrid Lang,
Christine Hoffmann,
Gernot Desoye
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20
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BLOOD-LYMPHATIC VESSEL INTEGRITY REQUIRES SYK TYROSINE KINASE SIGNALING WITHIN THE ENDOTHELIAL CELL COMPARTMENT
We have identified a novel angiogenic signaling pathway that is required for normal blood-lymphatic endothelial cell separation during lymphatic development. Mice deficient for components of this sign...
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Eric Sebzda,
Chris Hibbard,
Farhad Abtahian,
Victor Tybulewicz,
Gary A Koretzky,
Mark L Kahn
et al.
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21
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COLLAGEN MEMBRANE-BOUND STENT ALLOWS ADENOVIRUS-MEDIATED GENE DELIVERY TO PORCINE CORONARY ARTERIES
Coronary stenting is now an effective and widely employed percutaneous treatment for coronary artery disease. Unfortunately the long-term efficacy of this procedure is limited by recurrent luminal nar...
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Clare E Appleby,
Paul A Kingston,
Michel Verhoeven,
Anthony M Heagerty
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21
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IDENTIFICATION OF THE GENE CAUSING CM-AVM, A HERETOFORE UNDESCRIBED CLINICAL ENTITY, CHARACTERIZED BY DEFECTS IN CAPILLARY MORPHOGENESIS, ARTERIAL/VENOUS IDENTITY AND CONTROL OF LOCAL TISSUE GROWTH
Defects in cutaneous vascular development manifest as vascular malformations that vary in size, location, blood flow, and clinical severity. Capillary malformation (CM), (“port-wine stain”), (OMIM#163...
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Laurence M Boon,
Iiro Eerola,
John B Mulliken,
Patricia E Burrows,
Romain Vanwijck,
Miikka Vikkula
et al.
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22
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C 677T METHYLENTETRAHYDROFOLATE REDUKTASE (MTHFR) POLYMORPHISMS AND THROMBANGIITIS OBLITERANS
Thrombangiitis obliterans (TAO) is a non-atherosclerotic segmental arterial occlusive disease, which affects the small and medium sized arteries of predominantly young males with a strong history of s...
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Marianne Brodmann,
Wilfried Renner,
Gerald Seinost,
Ernst Pilger
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22
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