Cardiovascular Pathology
Volume 9, Issue 1 , Pages 53-54 , January 2000

Severe Heart Valve Calcification in a Young Patient with Werner Syndrome

  • Herko Grubitzsch, MD

      Affiliations

    • Clinic for Cardiothoracic and Vascular Surgery, Heart and Diabetes Centre Mecklenburg-Vorpommern, Klinikum Karlsburg, Germany
    • Corresponding Author InformationAddress for correspondence: Dr. H. Grubitzsch, Klinik für Herz-, Thorax- und Gefäßchirurgie, Herz- und Diabetes-Zentrum Mecklenburg-Vorpommern, Klinikum Karlsburg, Greifswalder Str. 11 A, D-17495 Karlsburg, Germany; Tel.: 004938355/701330; Fax: 004938355/701577,
    • ,
  • Sven Beholz, MD

      Affiliations

    • Clinic for Cardiothoracic and Vascular Surgery, Heart and Diabetes Centre Mecklenburg-Vorpommern, Klinikum Karlsburg, Germany
    • ,
  • Hans-Georg Wollert, MD

      Affiliations

    • Clinic for Cardiothoracic and Vascular Surgery, Heart and Diabetes Centre Mecklenburg-Vorpommern, Klinikum Karlsburg, Germany
    • ,
  • Lothar Eckel, MD

      Affiliations

    • Clinic for Cardiothoracic and Vascular Surgery, Heart and Diabetes Centre Mecklenburg-Vorpommern, Klinikum Karlsburg, Germany

Received 21 July 1999 ,Revised 11 October 1999 ,Accepted 11 November 1999.

References 

  1. Werner O. Ueber Katarkt in Verbindung mit Sklerodermie. Kiel: Universität Kiel;; 1904;[Inaugural-Dissertation]
  2. Epstein CJ, Martin GM, Schultz AL, Motulsky AG. Werner's syndrome (A review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process). Medicine. 1966;45:177–227
  3. Cohen Ji Arnett EN, Kolodny AL, Roberts WC. Cardiovascular features of the Werner syndrome. Am J Cardiol. 1987;59:493–495
  4. Rolle F, Cornu E, Virot P, Chauvreau C, Christides C, Laskar M. Calcified aortic valvular disease associated with adult progeria. Arch Mal Coeur Vaiss. 1997;90:1663–1665
  5. Nakura J, Wijsman EM, Miki T, et al.  Homozygosity mapping of the werner syndrome locus (WRN). Genomics. 1994;23:600–608
  6. Yu CE, Oshima J, Wijsman EM, et al.  Mutations in the consensus helicase domains of the werner syndrome gene. Am J Hum Genet. 1997;60:330–341

☆ Present affiliation for Dr. Beholz: Clinic for Cardiac Surgery, Humboldt University, Charité, Berlin, Germany.

PII: S1054-8807(99)00036-8

Cardiovascular Pathology
Volume 9, Issue 1 , Pages 53-54 , January 2000

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