Cardiovascular Pathology
Volume 9, Issue 1 , Pages 33-37 , January 2000

In Situ Interleukin-6 Transcription in Embryonic Nonmuscle Myosin Heavy Chain Expressing Immature Mesenchyme Cells of Cardiac Myxoma

  • Jun-ichi Suzuki, MD

      Affiliations

    • First, Shinshu University School of Medicine, Matsumoto, Japan
    • Corresponding Author InformationAddress for correspondence: Dr. Jun-ichi Suzuki, Vascular Medicine and Atherosclerosis Unit, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, 221 Longwood Ave, LMRC #307, Boston, MA 02115, U.S.A. Tel: ++1-617-732-6628; Fax: ++1-617-732-6961
    • ,
  • Kei Takayama, BS

      Affiliations

    • First, Shinshu University School of Medicine, Matsumoto, Japan
    • ,
  • Fujio Mitsui, MD

      Affiliations

    • First, Shinshu University School of Medicine, Matsumoto, Japan
    • ,
  • Tetsuya Kono, MD

      Affiliations

    • Second Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan
    • ,
  • Yoshikazu Yazaki, MD

      Affiliations

    • First, Shinshu University School of Medicine, Matsumoto, Japan
    • ,
  • Manabu Takei, MD

      Affiliations

    • Second Departments of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    • ,
  • Jun Amano, MD

      Affiliations

    • Second Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan
    • ,
  • Mitsuaki Isobe, MD

      Affiliations

    • First, Shinshu University School of Medicine, Matsumoto, Japan

Received 21 December 1998 ,Accepted 5 October 1999.

References 

  1. Burke AP, Virmani R. Cardiac myxoma. A clinicopathologic study. Am J Clin Pathol. 1993;100:671–680
  2. Roberts WC. Primary and secondary neoplasms of the heart. Am J Cardiol. 1997;80:671–682
  3. Reynen K. Cardiac myxomas. N Eng J Med. 1995;333:1610–1617
  4. Nagai R, Kuro-o M, Babij P, Periasamy M. Identification of two types of smooth muscle myosin heavy chain isoforms by cDNA cloning and immunoblot analysis. J Biol Chem. 1989;264:9734–9737
  5. Kuro-o M, Nagai R, Tsuchimochi H, Katoh H, Yazaki Y, Ohkubo A, et al. Developmentally regulated expression of vascular smooth muscle myosin heavy chain isoforms. J Biol Chem. 1989;264:18272–18275
  6. Kim HS, Aikawa M, Kimura K, Kuro-o M, Nakahara K, Suzuki T, et al. Ductus arteriosus, advanced differentiation of smooth muscle cells demonstration by myosin heavy chain isoform expression in rabbits. Circulation. 1993;88:1804–1810
  7. Kuro-o M, Nagai R, Nakahara K, Katoh H, Tsai RC, Tsuchimochi H, et al. cDNA cloning of a myosin heavy chain isoform in embryonic smooth muscle and its expression during vascular development and in arteriosclerosis. J Biol Chem. 1991;266:3768–3773
  8. Aikawa M, Sivam PN, Kuro-o M, Kimura M, Nakahara K, Takewaki S, et al. Human smooth muscle myosin heavy chain isoforms as molecular markers for vascular development and atherosclerosis. Circ Res. 1993;73:1000–1013
  9. Suzuki J, Isobe M, Aikawa M, Kawauchi M, Shiojima I, Kobayashi N, et al. Nonmuscle and smooth muscle myosin heavy chain expression in rejected cardiac allografts (a study in rat and monkey models). Circulation. 1996;94:1118–1124
  10. Bishop GA, Rokahr KL, Napoli J, McCaughan GW. Intragraft cytokine mRNA levels in human liver allograft rejection analyzed by reverse transcription and semiquantitative polymerase chain reaction amplification. Transplant Immunol. 1993;1:253–261
  11. Patel GV, Shum-siu A, Henifold BW, Wieman TJ, Hendler FJ. Detection of epidermal growth factor receptor mRNA in tissue sections from biopsy specimens using in situ polymerase chain reaction. Am J Pathol. 1994;144:7–14
  12. Nuovo GJ, Gallery F, MacConnell P, Braun A. In situ detection of polymerase chain reaction-amplified HIV-1 nucleic acids and tumor necrosis factor-alpha RNA in the central nervous system. Am J Pathol. 1994;144:659–666
  13. Curschellas E, Toia D, Borner M, Mihatsch MJ, Gudat F. Cardiac myxomas (immunohistochemical study of benign and malignant variants). Virchows Arch. 1991;418:485–491
  14. Hiroi J, Kimura K, Aikawa M, Tojo A, Suzuki Y, Nagamatsu T, et al. Expression of a nonmuscle myosin heavy chain in glomerular cells differentiates various types of glomerular disease in rats. Kidney Int. 1996;49:1231–1241
  15. Kishimoto T, Akira S, Taga T. Interleukin-6 and its receptor (a paradigm for cytokines). Science. 1992;258:593–597

PII: S1054-8807(99)00031-9

Cardiovascular Pathology
Volume 9, Issue 1 , Pages 33-37 , January 2000

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