Cardiovascular Pathology
Volume 9, Issue 1 , Pages 39-47 , January 2000

In Utero Development of Hypertensive Necrotizing Pulmonary Arterial Lesions: Report of a Case Associated with Premature Closure of the Ductus Arteriosus and Pulmonary Hypoplasia

  • Calvin E Oyer, MD

      Affiliations

    • Departments of Pathology, Women and Infants' Hospital and Brown University School of Medicine, Providence, RI, USA
    • Corresponding Author InformationAddress for correspondence: Calvin E. Oyer, MD, Department of Pathology, Women and Infants' Hospital, Providence, RI 02906, USA. Tel: (401) 831-2465; Fax: (401) 274-5519
  • ,
  • Lloyd R Feit, MD

      Affiliations

    • Departments of Pediatrics, Women and Infants' Hospital and Brown University School of Medicine, Providence, RI, USA
  • ,
  • Beverly B Rogers, MD

      Affiliations

    • Department of Pathology, Children's Medical Center and Southwestern Medical School, University of Texas, Dallas, TX, USA
  • ,
  • Charles Kuhn, MD

      Affiliations

    • Department of Pathology, Memorial Hospital of Rhode Island, Pawtucket, RI, USA
    • Department of Pathology, Brown University School of Medicine, Providence, RI, USA

Received 8 July 1999 ,Accepted 23 September 1999.

References 

  1. Heath D, Edwards JE. The pathology of hypertensive pulmonary vascular disease. A description of six grades of structural changes in the pulmonary arteries with special reference to congenital cardiac septal defects. Circulation. 1958;18:533–547
  2. Roberts WC. A simple histologic classification of pulmonary arterial hypertension (Editorial). Am J Cardiol. 1986;58:385–386
  3. Wagenvoort CA. Grading of pulmonary vascular lesions—A reappraisal. Histopathol. 1981;5:595–598
  4. Saldena ME, Harley RA, Liebow AA, Carrington CB. Experimental extreme pulmonary hypertension and vascular disease in relation to polycythemia. Amer J Pathol. 1968;52:935–981
  5. Singer DB, Sung CJ, Wigglesworth JS. Fetal growth and maturation (With standards for body and organ development). In:  Wigglesworth JS,  Singer DB editor. Textbook of Fetal and Perinatal Pathology. Boston, MA: Blackwell; 1991;p. 11–47
  6. Eckner FAO, Brown BW, Davidson DL, Glagov S. Dimensions of normal human hearts after standard fixation by controlled pressure coronary perfusion. Arch Pathol. 1969;88:497–507
  7. Harlass FE, Duff P, Brady K, Read J. Hydrops fetalis and premature closure of the ductus arteriosus (A review). Obstet Gynecol Survey. 1989;44:541–543
  8. Rao BN, Anderson RC, Edwards JE. Anatomic variations in the tetralogy of Fallot. Am Heart J. 1971;81:361–371
  9. Arcilla RA, Thilenius OG, Ranninger K. Congestive heart failure from suspected ductal closure in utero. J Pediatr. 1969;75:74–78
  10. Kohler HG. Premature closure of the ductus arteriosus (P.C.D.A.) (A possible cause of intrauterine circulatory failure). Early Human Development. 1978;2(1):15–23
  11. Mohen D, Newnham JP, D'Orsogna L. Indomethacin for the treatment of polyhydramnios (A case of constriction of the ductus arteriosus). Aust NZ Obstet Gynaecol. 1992;32:243–246
  12. Hallak M, Reiter AA, Ayres NA, Moise KJ. Indomethacin for preterm labor (Fetal toxicity in a dizygotic twin gestation). Obstet Gynecol. 1991;78:911–913
  13. Truter PJ, Franszen S, van der Merwe JV, Coetzee MJ. Premature closure of the ductus arteriosus causing intra-uterine death (A case report). S Afr Med J. 1986;70:557–558
  14. Becker AE, Becker MJ, Wagenvoort CA. Premature contraction of the ductus arteriosus (A cause of foetal death). J Pathol. 1977;121:187–191
  15. Chao R-C, Ho ES-C, Hsieh K-S. Doppler echocardiographic diagnosis of intrauterine closure of the ductus arteriosus. Prenat Diagn. 1993;13:989–994
  16. Huhta JC, Cohen AW, Wood DC. Premature constriction of the ductus arteriosus. J Am Soc Echo. 1990;3:30–34
  17. Berry TE, Muster AJ, Paul MH. Transient neonatal tricuspid regurgitation (Possible relation with premature closure of the ductus arteriosus). J Am Coll Cardiol. 1983;2:1178–1182
  18. Feit LR, Copel JA, Kleinman CS. Foramen ovale size in the normal and abnormal human fetal heart (an indicator of transatrial flow physiology). Ultrasound Obstet Gynecol. 1991;1:313–319
  19. Popek EJ, Strain JD, Neumann A, Wilson H. In utero development of pulmonary arterial calcification in monochorionic twins (A report of three cases and discussion of the possible etiology). Pediatr Pathol. 1993;13:597–611
  20. Haller JA, Morgan WW, Rodgers BM, Gengos DG, Margulies SI. Chronic hemodynamic effects of occluding the fetal ductus arteriosus. J Thorac Cardiovasc Surg. 1967;54:770–776
  21. Levin DL, Rudolph AM, Heymann MA, Phibbs RH. Morphological development of the pulmonary vascular bed in fetal lambs. Circ. 1976;53:144–151
  22. Levin DL, Mills LJ, Weinberg AG. Hemodynamic, pulmonary vascular, and myocardial abnormalities secondary to pharmacologic constriction of the fetal ductus arteriosus. Circ. 1979;60:360–364
  23. Wild LM, Nickerson PA, Morin FC. Ligating the ductus arteriosus before birth remodels the pulmonary vasculature of the lamb. Pediatr Res. 1989;25:251–257
  24. Downing GJ, Thibeault DW. Pulmonary vasculature changes associated with idiopathic closure of the ductus arteriosus and hydrops. Pediatr Cardiol. 1994;15:71–75
  25. Tada T, Wakabayashi T, Inagawa A, Togari H, Kishimoto H. Intrauterine closure of the ductus arteriosus in association with prune belly syndrome. Hum Pathol. 1985;16:952–955
  26. Bjornsson J, Edwards WD. Primary pulmonary hypertension (A histopathologic study of 80 cases). Mayo Clin Proc. 1985;60:16–25
  27. Askenazi SS, Perlman M. Pulmonary hypoplasia (Lung weight and radial alveolar count as criteria of diagnosis). Arch Dis Child. 1979;54:614–618
  28. Wigglesworth JS, Desai R, Guerrini P. Fetal lung hypoplasia (Biochemical and structural variations and their possible significance). Arch Dis Child. 1981;56:606–615
  29. Chamberlain D, Hislop A, Hey E, Reid L. Pulmonary hypoplasia in babies with severe rhesus isoimmunisation (A quantitative study). J Pathol. 1977;122:43–52
  30. Yamaki S, Wagenvoort CA. Plexogenic pulmonary arteriopathy. Significance of medial thickness with respect to advanced pulmonary vascular lesions. Am J Pathol. 1981;105:70–75

PII: S1054-8807(99)00030-7

Cardiovascular Pathology
Volume 9, Issue 1 , Pages 39-47 , January 2000