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Molecular changes in the heart of a severe case of arrhythmogenic right ventricular cardiomyopathy caused by a desmoglein-2 null allele

  • Katja Gehmlich

      Affiliations

    • Institute of Cardiovascular Science and The Heart Hospital, University College London, United Kingdom
    • Corresponding Author InformationCorresponding author. Present address: Department of Cardiovascular Medicine, University of Oxford, Level 6, West Wing, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, United Kingdom. Tel.: +44 0 1865 234902, fax: +44 0 1865 234681.
  • ,
  • Petros Syrris

      Affiliations

    • Institute of Cardiovascular Science and The Heart Hospital, University College London, United Kingdom
  • ,
  • Mareike Reimann

      Affiliations

    • Institute of Cardiovascular Science and The Heart Hospital, University College London, United Kingdom
  • ,
  • Angeliki Asimaki

      Affiliations

    • Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, United States
  • ,
  • Elisabeth Ehler

      Affiliations

    • King's College London, The Randall Division of Cell and Molecular Biophysics and the Cardiovascular Division, BHF Centre of Research Excellence, United Kingdom
  • ,
  • Alison Evans

      Affiliations

    • Institute of Cardiovascular Science and The Heart Hospital, University College London, United Kingdom
  • ,
  • Giovanni Quarta

      Affiliations

    • Institute of Cardiovascular Science and The Heart Hospital, University College London, United Kingdom
    • Department of Cardiology, S. Andrea Hospital, University “La Sapienza,” Rome, Italy
  • ,
  • Antonis Pantazis

      Affiliations

    • Institute of Cardiovascular Science and The Heart Hospital, University College London, United Kingdom
  • ,
  • Jeffrey E. Saffitz

      Affiliations

    • Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, United States
  • ,
  • William J. McKenna

      Affiliations

    • Institute of Cardiovascular Science and The Heart Hospital, University College London, United Kingdom

Received 31 May 2011 ,Revised 29 July 2011 ,Accepted 16 September 2011. Published online 31 October 2011 Corrected Proof

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 Sources of funding: This work was supported by the British Heart Foundation (program grant RG/04/010 to K.G., P.S., and W.J.M.), the Heart Rhythm Society (to A.A.), and the National Institutes of Health (HL102361 to J.E.S.). G.Q. is supported by a PhD Fellowship from the University “La Sapienza” of Rome and a European Society of Cardiology Research Fellowship. M.R. was supported by the European Commission ERASMUS Programme. Part of this work was undertaken at University College London/Hospital which received a proportion of funding from the Department of Health’s National Institute for Health Research Biomedical Research Centre.

 Conflict of interest: none declared.

PII: S1054-8807(11)00108-6

doi: 10.1016/j.carpath.2011.09.005

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Article in Press