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Cardiovascular Pathology
Volume 21, Issue 1
, Pages 28-38
, January 2012
Proteinase inhibitor 9 is reduced in human atherosclerotic lesion development
References
- . Coronary artery injury and the biology of atherosclerosis: inflammation, thrombosis, and stabilization. Am J Cardiol. 2000;86(8B):3J–8Jdiscussion 8J–9J
- . Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 2005;352(16):1685–1695
- . Apoptosis is abundant in human atherosclerotic lesions, especially in inflammatory cells (macrophages and T cells), and may contribute to the accumulation of gruel and plaque instability. Am J Pathol. 1996;149(2):367–380
- . Apoptosis in atherosclerosis: beneficial or detrimental?. Cardiovasc Res. 2000;45(3):736–746
- Granzyme B in atherosclerosis and transplant vascular disease: association with cell death and atherosclerotic disease severity. Mod Pathol. 2003;16(5):460–470
- . The role of granzyme B in atheromatous diseases. Can J Physiol Pharmacol. 2007;85(1):89–95
- . Granzymes in age-related cardiovascular and pulmonary diseases. Cell Death Differ. 2010;17(4):596–606
- . Perforin-mediated target-cell death and immune homeostasis. Nat Rev Immunol. 2006;6(12):940–952
- Granzyme B induces smooth muscle cell apoptosis in the absence of perforin: involvement of extracellular matrix degradation. Arterioscler Thromb Vasc Biol. 2004;24(12):2245–2250
- Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin. J Biol Chem. 2005;280(25):23549–23558
- . degrades aggrecan proteoglycan in matrix synthesized by chondrocytes. J Immunol. 1993;151(12):7161–7171
- . Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma. Lab Invest. 2009;89(11):1195–1220
- Perforin-independent extracellular granzyme B activity contributes to abdominal aortic aneurysm. Am J Pathol. 2010;176(2):1038–1049
- Elevation of plasma granzyme B levels after acute myocardial infarction. Circ J. 2009;73(3):503–507
- Plasma levels of granzyme B are increased in patients with lipid-rich carotid plaques as determined by echogenicity. Atherosclerosis. 2007;195(2):e142–e146
- Increased granzyme B production from peripheral blood mononuclear cells in patients with acute coronary syndrome. Heart. 2008;94(3):305–310
- A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes. J Biol Chem. 1996;271(44):27802–27809
- . Control of granzymes by serpins. Cell Death Differ. 2010;17(4):586–595
- The granzyme B inhibitor, protease inhibitor 9, is mainly expressed by dendritic cells and at immune-privileged sites. J Immunol. 2001;166(5):3218–3225
- . The granzyme B. inhibitor, PI-9, is present in endothelial and mesothelial cells, suggesting that it protects bystander cells during immune responses. Cell Immunol. 2001;210(1):21–29
- . The serpin proteinase inhibitor 9 is an endogenous inhibitor of interleukin 1beta-converting enzyme (caspase-1) activity in human vascular smooth muscle cells. J Exp Med. 2000;191(9):1535–1544
- Biglycan, decorin, and versican protein expression patterns in coronary arteriopathy of human cardiac allograft: distinctness as compared to native atherosclerosis. J Heart Lung Transplant. 1996;15(12):1233–1247
- . Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2000;20(5):1262–1275
- . Hyperexpression of the granzyme B inhibitor PI-9 in human renal allografts: a potential mechanism for stable renal function in patients with subclinical rejection. Kidney Int. 2004;66(4):1417–1422
- . The granzyme B inhibitor PI-9 is differentially expressed in all main subtypes of pediatric acute lymphoblastic leukemias. Haematologica. 2004;89(11):1314–1321
- Bosentan enhances viral load via endothelin-1 receptor type-A-mediated p38 mitogen-activated protein kinase activation while improving cardiac function during coxsackievirus-induced myocarditis. Circ Res. 2009;104(6):813–821
- . Collagen matrix remodeling in 3-dimensional cellular space resolved using second harmonic generation and multiphoton excitation fluorescence. J Struct Biol. 2010;169(1):36–44
- . The phenotypes of smooth muscle expressed in human atheroma. Ann N Y Acad Sci. 1990;598:143–158
- . Risk of thrombosis in human atherosclerotic plaques: role of extracellular lipid, macrophage, and smooth muscle cell content. Br Heart J. 1993;69(5):377–381
- . Coronary risk factors and plaque morphology in men with coronary disease who died suddenly. N Engl J Med. 1997;336(18):1276–1282
- . Improved detection of apoptotic cells in archival paraffin sections: immunohistochemistry using antibodies to cleaved caspase 3. J Histochem Cytochem. 2002;50(4):449–454
- Cytotoxic T lymphocyte-assisted suicide. Caspase 3 activation is primarily the result of the direct action of granzyme B. J Biol Chem. 1998;273(33):21261–21266
- Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors. Proc Natl Acad Sci U S A. 2001;98(20):11515–11520
- Expression of the granzyme B inhibitor, protease inhibitor 9, by tumor cells in patients with non-Hodgkin and Hodgkin lymphoma: a novel protective mechanism for tumor cells to circumvent the immune system?. Blood. 2002;99(1):232–237
- Expression levels of apoptosis-related proteins predict clinical outcome in anaplastic large cell lymphoma. Blood. 2002;99(12):4540–4546
- . Arterial smooth muscle cell heterogeneity: implications for atherosclerosis and restenosis development. Arterioscler Thromb Vasc Biol. 2003;23(9):1510–1520
- . Atherosclerosis-an inflammatory disease. N Engl J Med. 1999;340(2):115–126
- . Smooth muscle cell origin and its relation to heterogeneity in development and disease. Arterioscler Thromb Vasc Biol. 1999;19(7):1589–1594
- . Diverse origin of intimal cells: smooth muscle cells, myofibroblasts, fibroblasts, and beyond?. Circ Res. 2002;91(8):652–655
- Enhanced H(2)O(2)-induced cytotoxicity in “epithelioid” smooth muscle cells: implications for neointimal regression. Arterioscler Thromb Vasc Biol. 2000;20(6):1473–1479
- . Phenotypic heterogeneity influences apoptotic susceptibility to retinoic acid and cis-platinum of rat arterial smooth muscle cells in vitro: Implications for the evolution of experimental intimal thickening. Arterioscler Thromb Vasc Biol. 2001;21(7):1118–1123
- . Sensitivity to Fas-mediated apoptosis is determined below receptor level in human vascular smooth muscle cells. Circ Res. 2000;86(10):1038–1046
- . The emerging role of vascular smooth muscle cell apoptosis in atherosclerosis and plaque stability. Am J Nephrol. 2006;26(6):531–535
- Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis. Nat Med. 2006;12(9):1075–1080
- Chronic apoptosis of vascular smooth muscle cells accelerates atherosclerosis and promotes calcification and medial degeneration. Circ Res. 2008;102(12):1529–1538
- . Apoptotic cell death in atherosclerosis. Curr Opin Lipidol. 2003;14(5):469–475
- . The role of serpinb9/serine protease inhibitor 6 in preventing granzyme B-dependent hepatotoxicity. Hepatology. 2007;46(5):1530–1540
- The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency. J Immunol. 2003;170(2):805–815
- Expression of the serpin serine protease inhibitor 6 protects dendritic cells from cytotoxic T lymphocyte-induced apoptosis: differential modulation by T helper type 1 and type 2 cells. J Exp Med. 2001;194(5):657–667
This research was funded in part from grants from the Heart and Stroke Foundation of British Columbia and Yukon (HSFBCY) (DJG) and the Canadian Institutes for Health Research (CIHR) (MFA, DJG). Funding sources: AH is grateful for the support from a CIHR Canada Graduate Scholarship Master's Award and the Vanier Canada Graduate Scholarship. DC is funded by the HSFBCY, CIHR/IMPACT, and NSERC Fellowship.
PII: S1054-8807(10)00198-5
doi: 10.1016/j.carpath.2010.12.002
© 2012 Elsevier Inc. All rights reserved.
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Cardiovascular Pathology
Volume 21, Issue 1
, Pages 28-38
, January 2012
