Cardiovascular Pathology
Volume 20, Issue 3 , Pages e91-e94 , May 2011

Smooth muscle cells in porcine vein graft intimal hyperplasia are derived from the local vessel wall

  • Marc Jevon

      Affiliations

    • Cardiovascular Sciences Unit, National Heart and Lung Institute, Imperial College London, Hammersmith Hospital, London, UK
    • ,
  • Tahera I. Ansari

      Affiliations

    • Department of Surgical Research (TA, PS), Northwick Park Institute for Medical Research, Harrow, UK
    • ,
  • Jonathan Finch

      Affiliations

    • Cardiovascular Sciences Unit, National Heart and Lung Institute, Imperial College London, Hammersmith Hospital, London, UK
    • ,
  • Mustafa Zakkar

      Affiliations

    • Cardiovascular Sciences Unit, National Heart and Lung Institute, Imperial College London, Hammersmith Hospital, London, UK
    • ,
  • Paul C. Evans

      Affiliations

    • Cardiovascular Sciences Unit, National Heart and Lung Institute, Imperial College London, Hammersmith Hospital, London, UK
    • ,
  • Sandra Shurey

      Affiliations

    • Cardiovascular Sciences Unit, National Heart and Lung Institute, Imperial College London, Hammersmith Hospital, London, UK
    • ,
  • Paul D. Sibbons

      Affiliations

    • Department of Surgical Research (TA, PS), Northwick Park Institute for Medical Research, Harrow, UK
    • ,
  • Phillip Hornick

      Affiliations

    • Cardiovascular Sciences Unit, National Heart and Lung Institute, Imperial College London, Hammersmith Hospital, London, UK
    • ,
  • Dorian O. Haskard

      Affiliations

    • Cardiovascular Sciences Unit, National Heart and Lung Institute, Imperial College London, Hammersmith Hospital, London, UK
    • ,
  • Anthony Dorling

      Affiliations

    • Department of Immunology, Imperial College London, Hammersmith Hospital, London, UK
    • Corresponding Author InformationCorresponding author. MRC Centre for Transplantation, King's College London, SE1 9RT London, UK. Tel.: +44 20 7188 5880; fax: +44 20 7188 5660.
    • Current address: MRC Centre for Transplantation, King's College London, Guy's Hospital, London SE1 9RT.

Received 20 January 2010 ,Revised 6 April 2010 ,Accepted 19 April 2010.

References 

  1. Goldman S, Zadina K, Moritz T, Ovitt T, Sethi G, Copeland JG, et al. Long-term patency of saphenous vein and left internal mammary artery grafts after coronary artery bypass surgery: results from a Department of Veterans Affairs Cooperative Study. J Am Coll Cardiol. 2004;44:2149–2156
  2. Hu Y, Mayr M, Metzler B, Erdel M, Davison F, Xu Q. Both donor and recipient origins of smooth muscle cells in vein graft atherosclerotic lesions. Circ Res. 2002;91:e13–e20
  3. Chen D, Weber M, Shiels PG, Dong R, Webster Z, McVey JH, et al. Post-injury vascular intimal hyperplasia in mice is completely inhibited by CD34+ bone marrow-derived progenitor cells expressing membrane-tethered anticoagulant fusion proteins. J Thromb Haemost. 2006;4:2191–2198
  4. Zou Y, Dietrich H, Hu Y, Metzler B, Wick G, Xu Q. Mouse model of venous bypass graft arteriosclerosis. Am J Pathol. 1998;153:1301–1310
  5. Fogelstrand P, Osterberg K, Mattsson E. Reduced neointima in vein grafts following a blockage of cell recruitment from the vein and the surrounding tissue. Cardiovasc Res. 2005;67:326–332

 The authors declare no conflicts of interest.

PII: S1054-8807(10)00062-1

doi: 10.1016/j.carpath.2010.04.003

Cardiovascular Pathology
Volume 20, Issue 3 , Pages e91-e94 , May 2011

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