Cardiovascular Pathology
Volume 20, Issue 1 , Pages e43-e52 , January 2011

Ischemic myocardial injuries after cardiac malformation repair in infants may be associated with oxidative stress mechanisms

  • Marcela S. Oliveira

      Affiliations

    • Department of Pathology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14049-900 Ribeirão Preto, SP, Brazil
  • ,
  • Elaine M. Floriano

      Affiliations

    • Department of Pathology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14049-900 Ribeirão Preto, SP, Brazil
  • ,
  • Suleimy C. Mazin

      Affiliations

    • Department of Statistics, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14049-900 Ribeirão Preto, SP, Brazil
  • ,
  • Edson Z. Martinez

      Affiliations

    • Department of Statistics, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14049-900 Ribeirão Preto, SP, Brazil
  • ,
  • Walter V.A. Vicente

      Affiliations

    • Department of Surgery and Anatomy, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14049-900 Ribeirão Preto, SP, Brazil
  • ,
  • Luiz C. Peres

      Affiliations

    • Department of Pathology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14049-900 Ribeirão Preto, SP, Brazil
    • Department of Histopathology, Sheffield Children's NHS Foundation Trust, Sheffield, England
  • ,
  • Marcos A. Rossi

      Affiliations

    • Department of Pathology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14049-900 Ribeirão Preto, SP, Brazil
  • ,
  • Simone G. Ramos

      Affiliations

    • Department of Pathology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14049-900 Ribeirão Preto, SP, Brazil
    • Corresponding Author InformationCorresponding author. Department of Pathology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Av. Bandeirantes 3900 14049-900 Ribeirão Preto, SP, Brazil. Tel.: +55 16 36023341; fax: +55 16 36023341.

Received 3 June 2009 ,Revised 12 January 2010 ,Accepted 26 January 2010.

References 

  1. Bull C, Cooper J, Stark J. Cardioplegic protection of the child's heart. J Thorac Cardiovasc Surg. 1984;88:287–293
  2. Taggart DP, Hadjinikolas L, Hooper J, Albert J, Kemp M, Hue D, et al. Effects of age and ischemic times on biochemical evidence of myocardial injury after pediatric cardiac operations. J Thorac Cardiovasc Surg. 1997;113:728–735
  3. Modi P, Imura H, Caputo M, Pawade A, Parry A, Angelini GD, et al. Cardiopulmonary bypass-induced myocardial reoxygenation injury in cyanotic pediatric patients. J Thorac Cardiovasc Surg. 2002;124:1035–1036
  4. Elias DO, Souza MHL. Injúria e proteção do miocárdio em neonatos. Rev Latinoam Tecnol Extracorp. 2004;11:2;http://perfline.com/revista/volume11/v11n2/[accessed October 21, 2008]
  5. Fishbein MC, Maclean D, Maroko PR. The histopathologic evolution of myocardial infarction. Chest. 1978;73:843–849
  6. Todd GL, Baroldi G, Pieper GM, Clayton FC, Eliot RS. Experimental catecholamine-induced myocardial necrosis: II. Temporal development of isoproterenol-induced contraction band lesions correlated with ECG, hemodynamic and biochemical changes. J Mol Cell Cardiol. 1985;17:647–656
  7. Virmani R, Farb A, Burke A. Contraction band necrosis: a new use for an old friend. Lancet. 1996;347:1710–1711
  8. Baroldi G, Silver MD, De Maria R, Gronda E, Pellegrini A. Pathology and pathogenesis of congestive heart failure. A quantitative morphologic study of 144 hearts excised at transplantation. Pathogenesis. 1998;1:107–122
  9. Turillazzi E, Baroldi G, Silver MD, Parolini M, Pomara C. A systematic study of a myocardial lesion: colliquative myocytolysis. Int J Cardiol. 2005;104:152–157
  10. Weibel ER. Stereological methods. In: Practical Methods for Biological Morphometry. London: Academic Press; 1979;p. 415
  11. Angers JF, Biswas AA. Bayesian analysis of zero-inflated generalized Poisson model. Comput Stat Data Anal. 2003;42:237–246
  12. Mazin SC, Oliveira MS, Martinez EZ, Achcar JA, Ramos SG. Uso de um modelo Bayesiano de Poisson com excesso de zeros na análise de dados de lesões miocárdicas em recém-nascidos com cardiopatias congênitas complexas. Rev Bras Biom. 2008;26:113–125
  13. Hammon JW. Myocardial protection in the immature heart. Ann Thorac Surg. 1995;60:839–842
  14. Milei J, Nunes RG, Bolomo NJ. Isoproterenol induced Ca uptake into myocardium of rats. Res Exp Med. 1979;176:117–121
  15. Carmona F, Manso PH, Vicente WAV, Castro M, Carlotti APCP. Risk stratification in neonates and infants submitted to cardiac surgery with cardiopulmonary bypass: a multimarker approach combining inflammatory mediators, N-terminal pro-B-type natriuretic peptide and troponin I. Cytokine. 2008;42:317–324
  16. Seghaye MC, Engelhardt W, Grabitz RG, Faymonville ME, Hornchen H, Messmer BJ, et al. Multiple system organ failure after open heart surgery in infants and children. Thorac Cardiovasc Surg. 1993;41:49–53
  17. Baroldi G, Oliveira SJ, Silver MD. Sudden and unexpected death in clinically ‘silent’ Chagas' disease. A hypothesis. Int J Cardiol. 1997;58:263–268
  18. Kato R, Ross S, Foëx P. Fentanyl protects the heart against ischaemic injury via opioid receptors, adenosine A1 receptors and KATP channel linked mechanisms in rats. Br J Anaesth. 2000;84:204–214
  19. Kevin LG, Novalija E, Stowe DF. Reactive oxygen species as mediators of cardiac injury and protection: the relevance to anesthesia practice. Anesth Analg. 2005;101:1275–1287
  20. Haenen GRMM, Plug HJM, Vermeulen NPE, Timmerman H, Bast A. Contribution of 4-hydroxy-2,3-trans-nonenal to the reduction of β-adrenoceptor function in the heart by oxidative stress. Life Sci. 1989;45:71–76
  21. Blasig IE, Schoenheit K, Siems WG. Formation of 4-hydroxyalkenals by the reperfusion-injured rat heart. Ann N Y Acad Sci. 1994;723:462–465
  22. Eaton P, Li J, Hearse DJ, Shattock MJ. Formation of 4-hydroxy-2-nonenal-modified proteins in ischemic rat heart. Am J Physiol Heart Circ Physiol. 1999;276:H935–H943
  23. Kaminski K, Bonda T, Wojtkowska I, Dobrzycki S, Kralisz P, Nowak K, et al. Oxidative stress and antioxidative defense parameters early after reperfusion therapy for acute myocardial infarction. Acute Card Care. 2008;10:121–126
  24. Schömig A. Catecholamines in myocardial ischemia. Systemic and cardiac release. Circulation. 1990;82(3 Suppl):II13–II22
  25. Neri M, Cerretani D, Fiaschi AI, Laghi PF, Lazzerini PE, Maffione AB, et al. Correlation between cardiac oxidative stress and myocardial pathology due to acute and chronic norepinephrine administration in rats. J Cell Mol Med. 2007;11:156–170
  26. Campos EC, Romano MMD, Prado CM, Rossi MA. Isoproterenol induces primary loss of dystrophin in rat hearts: correlation with myocardial injury. Int J Exp Pathol. 2008;89:367–381
  27. Singal PK, Kapur N, Dhillon KS, Beamish RE, Dhalla NS. Role of free radicals in catecholamine-induced cardiomyopathy. Can J Physiol Pharmacol. 1981;60:1390–1397
  28. Josephson RA, Silverman HS, Lakatta EG, Stern MD, Zweier JL. Study of the mechanism of hydrogen peroxide and hydroxyl free radical-induced cellular injury and calcium overload in cardiac myocytes. J Biol Chem. 1991;266:2354–2361
  29. Virag L, Szabo E, Gergely P, Szabo C. Peroxynitrite-induced cytotoxicity: mechanism and opportunities for intervention. Toxicol Lett. 2003;140-141:113–124
  30. Choi YH, Cowan DB, Moran AM, Colan SD, Stamm C, Takeuchi K, et al. Myocyte apoptosis occurs early during the development of pressure-overload hypertrophy in infant myocardium. J Thorac Cardiovasc Surg. 2009;137:1356–1362

 Conflict of interest: None of the authors of this article have a conflict of interest, and this article has not been published previously.

 Funding: Simone G. Ramos and Marcos A. Rossi are investigators of CNPq. Dr. Oliveira was a recipient of a Master of Science Degree from CNPq. This work was partially supported by Fundação de Apoio ao Ensino, Pesquisa e Assistência (FAEPA) (1299/2006).

PII: S1054-8807(10)00029-3

doi: 10.1016/j.carpath.2010.01.012

Cardiovascular Pathology
Volume 20, Issue 1 , Pages e43-e52 , January 2011