Cardiovascular Pathology
Volume 20, Issue 2 , Pages 110-113 , March 2011

Expression of hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN4) is increased in hypertrophic cardiomyopathy

  • Huang Wei-qing

      Affiliations

    • Department of Pathology, Qingdao Municipal Hospital, Qingdao 266071, Shandong, China
    • ,
  • Kong Qing-nuan

      Affiliations

    • Department of Pathology, Qingdao Municipal Hospital, Qingdao 266071, Shandong, China
    • ,
  • Xu Lin

      Affiliations

    • Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao 266071, Shandong, China
    • ,
  • Guo Cheng-hao

      Affiliations

    • Department of Pathology, Medical College of Shandong University, Jinan 250012, Shandong, China
    • ,
  • Zhang Qi-yi

      Affiliations

    • Department of Cardiology, Qingdao Municipal Hospital, Qingdao 266071, Shandong, China
    • Corresponding Author InformationCorresponding author. Department of Cardiology, Qingdao Municipal Hospital, 1 Jiaozhou Street, Qingdao 266071, Shandong Province, China.

Received 21 April 2009 ,Revised 22 November 2009 ,Accepted 5 January 2010.

References 

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  2. Richard RB, Sie gelbaum SA. Hyperpolarization-activated cation currents: from molecules to physiological function. Annu Revi Physiol. 2003;65(1):453–480
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  12. Stieber J, Herrmann S, Feil S, et al. The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart. Proc Natl Acad Sci USA. 2003;100(25):15235–15240
  13. Zagotta WN, Olivier NB, Black KD, et al. Structural basis for modulation and agonist specificity of HCN pacemaker channels. Nature. 2003;425(6954):200–205
  14. Schulze-Bahr E, Neu A, Friederich P, et al. Pacemaker channel dysfunction in a patient with sinus node disease. J Clin Invest. 2003;111(10):1537–1545
  15. Stillitano F, Lonardo G, Zicha S, et al. Molecular basis of funny current (If) in normal and failing human heart. J Mol Cell Cardiol. 2008;45(2):289–299
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 Our research was supported by Qingdao’s Science and Technology Development plan. The funding body was Qingdao City Science and Technology Burea.

PII: S1054-8807(10)00023-2

doi: 10.1016/j.carpath.2010.01.007

Cardiovascular Pathology
Volume 20, Issue 2 , Pages 110-113 , March 2011

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