Cardiovascular Pathology
Volume 20, Issue 1 , Pages e1-e7 , January 2011

Aortic aneurysms in systemic lupus erythematosus: a meta-analysis of 35 cases in the literature and two different pathogeneses

  • Atsushi Kurata

      Affiliations

    • Department of Pathology, Kyorin University School of Medicine, Tokyo, Japan
    • Corresponding Author InformationCorresponding author. Department of Pathology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka City, Tokyo 181-8611, Japan. Tel.: +81 422 47 5511 (4426); fax: +81 422 40 7093.
  • ,
  • Tomohiro Kawakami

      Affiliations

    • Kyorin University School of Medicine, Tokyo, Japan
  • ,
  • Junichiro Sato

      Affiliations

    • Kyorin University School of Medicine, Tokyo, Japan
  • ,
  • Atsuhiko Sakamoto

      Affiliations

    • Department of Pathology, Kyorin University School of Medicine, Tokyo, Japan
  • ,
  • Tsukasa Muramatsu

      Affiliations

    • Department of Health and Nutritional Science, Faculty of Human Health Science, Matsumoto University, Nagano, Japan
  • ,
  • Kimimasa Nakabayashi

      Affiliations

    • Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan

Received 26 October 2009 ,Revised 24 November 2009 ,Accepted 5 January 2010.

References 

  1. D'Cruz DP, Khamashta MA, Hughes GR. Systemic lupus erythematosus. Lancet. 2007;369:587–596
  2. Marubayashi S, Sugi K, Ishiyama K, et al. A case of abdominal aortic aneurysm associated with systemic lupus erythematosus. Hiroshima J Med Sci. 1998;47:85–87
  3. Sclair M, Nassar H, Bar-Ziv Y, Putterman C. Dissecting aortic aneurysm in systemic lupus erythematosus. Lupus. 1995;4:71–74
  4. Chang WL, Huang CM, Yang YH, Lin YT, Chiang BL. Aortic aneurysm in systemic lupus erythematosus. J Microbiol Immunol Infect. 2004;37:310–312
  5. Rapondjieva A, Dobreva N, Delijska B. A case of nondissecting abdominal aortic aneurysm associated with systemic lupus erythematosus. Nephrol Dial Transplant. 2001;16:1079–1080
  6. Nosaka S, Yamauchi M, Sasaki T, Ku K, Hanada T, Tamura K. Abdominal aortic aneurysm rupture in systemic lupus erythematosus. J Cardiovasc Surg (Torino). 1999;40:59–61
  7. Wang J, French SW, Chuang CC, McPhaul L. Pathologic quiz case: an unusual complication of systemic lupus erythematosus. Arch Pathol Lab Med. 2000;124:324–326
  8. Aoyagi S, Akashi H, Otsuka H, Sakashita H, Okazaki T, Tayama K. Acute type A aortic dissection in a patient with systemic lupus erythematosus. Jpn Heart J. 2002;43:567–571
  9. Khalil A, Helmy T, Porembka DT. Aortic pathology: aortic trauma, debris, dissection, and aneurysm. Crit Care Med. 2007;35(8 Suppl):S392–S400
  10. Dugo M, Liessi G, De Luca M, Arduini R, Susanna F, Cascone C. Dissection of the thoracic-abdominal aorta in a young adult with systemic lupus erythematosus. Clin Nephrol. 1993;39:349–351
  11. Ohara N, Miyata T, Kurata A, Oshiro H, Sato O, Shigematsu H. Ten years' experience of aortic aneurysm associated with systemic lupus erythematosus. Eur J Vasc Endovasc Surg. 2000;19:288–293
  12. Igarashi T, Nagaoka S, Matsunaga K, et al. Aortitis syndrome (Takayasu's arteritis) associated with systemic lupus erythematosus. J Rheumatol. 1989;16:1579–1583
  13. Kunihara T, Sasaki S, Nishibe T, et al. Successful endovascular stent-grafting for thoracic aortic aneurysms in systemic lupus erythematosus. Report of 2 cases and review of the literature. J Cardiovasc Surg (Torino). 2002;43:235–240
  14. Kameyama K, Kuramochi S, Ueda T, et al. Takayasu's aortitis with dissection in systemic lupus erythematosus. Scand J Rheumatol. 1999;28:187–188
  15. Choi KH, Rim SJ, Lee SK, Jang BC, Cho SH. Dissecting aortic aneurysm with aortic-valve insufficiency in systemic lupus erythematosus. Nephrol Dial Transplant. 1999;14:969–973
  16. Sato J, Kawakami T, Nakabayashi K, et al. Multiple aortic aneurysms complicated by a rupture in the systemic lupus erythematosus: a case report. Pathol Res Pract. 2008;204:845–850
  17. Walts AE, Dubois EL. Acute dissecting aneurysm of the aorta as the fatal event in systemic lupus erythematosus. Am Heart J. 1977;93:378–381
  18. Arul Rajamurugan PS, Panchapakesa Rajendran C, Rukmangatharajan S, Kanakarani P, Rajeswari S, Ravichandran R. Aortic dissection in a case of systemic lupus erythematosus. Lupus. 2007;16:1001–1003
  19. Lam KY, Cheung F, Yam LY, Lee CH, Fung KH. Atypical manifestations in a patient with systemic lupus erythematosus. J Clin Pathol. 1997;50:174–176
  20. Bernhard GC, Lange RL, Hensley GT. Aortic disease with valvular insufficiency as the principal manifestation of systemic lupus erythematosus. Ann Intern Med. 1969;71:81–87
  21. Sato O, Takagi A, Miyata T, Takayama Y. Aortic aneurysms in patients with autoimmune disorders treated with corticosteroids. Eur J Vasc Endovasc Surg. 1995;10:366–369
  22. Rackley CE. Hormones and coronary atherosclerosis in women. Endocrine. 2004;24:245–250
  23. Insull W. The pathology of atherosclerosis: plaque development and plaque responses to medical treatment. Am J Med. 2009;122(1 Suppl):S3–14
  24. Jayalath RW, Mangan SH, Golledge J. Aortic calcification. Eur J Vasc Endovasc Surg. 2005;30:476–488
  25. Okiye SE, Sterioff S, Schaff HV, Engen DE, Zincke H. Acute dissecting aneurysm of the aorta after renal transplantation. J Urol. 1983;129:803–804
  26. Pazirandeh M, Ziran BH. Dissecting aortic aneurysm in a patient with SLE. J Rheumatol. 1988;15:525–526
  27. Chakravarty K, Scott DG. Mycotic aneurysm of the aortic arch masquerading as systemic lupus erythematosus. Ann Rheum Dis. 1992;51:1079–1081
  28. Stehbens WE, Delahunt B, Shirer WC, Naik DK. Aortic aneurysm in systemic lupus erythematosus. Histopathology. 1993;22:275–277
  29. Guard RW, Gotis-Graham I, Edmonds JP, Thomas AC. Aortitis with dissection complicating systemic lupus erythematosus. Pathology. 1995;27:224–228
  30. Hussain KM, Chandna H, Santhanam V, Sehgal S, Jain A, Denes P. Aortic dissection in a young corticosteroid-treated patient with systemic lupus erythematosus—a case report. Angiology. 1998;49:649–652
  31. Khan AS, Spiera H. Association of aortic aneurysm in patients with systemic lupus erythematosus: a series of case reports and a review of the literature. J Rheumatol. 1998;25:2019–2021
  32. Moro H, Hayashi J, Ohzeki H, Sogawa M, Nakayama T, Namura O. Surgical management of cardiovascular lesions caused by systemic inflammatory diseases. Thorac Cardiovasc Surg. 1999;47:106–110
  33. Washiyama N, Kazui T, Takinami M, et al. Surgical treatment of recurrent abdominal aortic aneurysm in a patient with systemic lupus erythematosus. J Vasc Surg. 2000;32:209–212
  34. Takagi H, Mori Y, Iwata H, et al. Nondissecting aneurysm of the thoracic aorta with arteritis in systemic lupus erythematosus. J Vasc Surg. 2002;35:801–804
  35. Guo DC, Papke CL, He R, Milewicz DM. Pathogenesis of thoracic and abdominal aortic aneurysms. Ann N Y Acad Sci. 2006;1085:339–352
  36. Carlson RG, Lillehei CW, Edwards JE. Cystic medial necrosis of the ascending aorta in relation to age and hypertension. Am J Cardiol. 1970;25:411–415
  37. Bulkley BH, Roberts WC. The heart in systemic lupus erythematosus and the changes induced in it by corticosteroid therapy. A study of 36 necropsy patients. Am J Med. 1975;58:243–264
  38. Hackam DG, Thiruchelvam D, Redelmeier DA. Angiotensin-converting enzyme inhibitors and aortic rupture: a population-based case-control study. Lancet. 2006;368:659–665
  39. Hata M, Sezai A, Niino T, et al. Prognosis for patients with type B acute aortic dissection: risk analysis of early death and requirement for elective surgery. Circ J. 2007;71:1279–1282
  40. Ruddy JM, Jones JA, Spinale FG, Ikonomidis JS. Regional heterogeneity within the aorta: relevance to aneurysm disease. J Thorac Cardiovasc Surg. 2008;136:1123–1130
  41. Sturfelt G, Nived O, Norberg R, Thorstensson R, Krook K. Anticardiolipin antibodies in patients with systemic lupus erythematosus. Arthritis Rheum. 1987;30:382–388

 Financial support: We declare that we have no funding source concerning this study.

PII: S1054-8807(10)00019-0

doi: 10.1016/j.carpath.2010.01.003

Cardiovascular Pathology
Volume 20, Issue 1 , Pages e1-e7 , January 2011