Cardiovascular Pathology
Volume 20, Issue 2 , Pages 99-106 , March 2011

Atrial myocardial nox2 containing NADPH oxidase activity contribution to oxidative stress in mitral regurgitation: potential mechanism for atrial remodeling

  • Jen-Ping Chang

      Affiliations

    • Division of Cardiovascular Surgery, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung Hsien 83301, Taiwan, Republic of China
  • ,
  • Mien-Cheng Chen

      Affiliations

    • Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung Hsien 83301, Taiwan, Republic of China
    • Corresponding Author InformationCorresponding author. Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung Hsien 83301, Taiwan, Republic of China. Tel.: +886 7 731 7123x8300; fax: +886 7 732 2402.
  • ,
  • Wen-Hao Liu

      Affiliations

    • Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung Hsien 83301, Taiwan, Republic of China
  • ,
  • Cheng-Hsu Yang

      Affiliations

    • Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung Hsien 83301, Taiwan, Republic of China
  • ,
  • Chien-Jen Chen

      Affiliations

    • Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung Hsien 83301, Taiwan, Republic of China
  • ,
  • Yung-Lung Chen

      Affiliations

    • Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung Hsien 83301, Taiwan, Republic of China
  • ,
  • Kuo-Li Pan

      Affiliations

    • Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung Hsien 83301, Taiwan, Republic of China
  • ,
  • Tzu-Hsien Tsai

      Affiliations

    • Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung Hsien 83301, Taiwan, Republic of China
  • ,
  • Hsueh-Wen Chang

      Affiliations

    • Department of Biological Sciences, National Sun Yat-Sen University, Taiwan, Republic of China

Received 26 April 2009 ,Revised 21 December 2009 ,Accepted 23 December 2009.

References 

  1. Heistad DD. Oxidative stress and vascular disease. Arterioscler Thromb Vasc Biol. 2006;26:689–695
  2. Corradi D, Callegari S, Maestri R, Benussi S, Bosio S, De Palma G, et al. Heme oxygenase-1 expression in the left atrial myocardium of patients with chronic atrial fibrillation related to mitral valve disease: its regional relationship with structural remodeling. Hum Pathol. 2008;39:1162–1171
  3. Cheng W, Li B, Kajstura J, Li P, Wolin MS, Sonnenblick EH, et al. Stretch-induced programmed myocyte cell death. J Clin Invest. 1995;96:2247–2259
  4. Pimentel DR, Amin JK, Xiao L, Miller T, Viereck J, Oliver-Krasinski J, et al. Reactive oxygen species mediate amplitude-dependent hypertrophic and apoptotic responses to mechanical stretch in cardiac myocytes. Circ Res. 2001;89:453–460
  5. Chen MC, Chang JP, Huang SC, Chang HW, Chen CJ, Yang CH, et al. Dedifferentiation of atrial cardiomyocytes in cardiac valve disease: unrelated to atrial fibrillation. Cardiovasc Pathol. 2008;17:156–165
  6. Kostin S, Klein G, Szalay Z, Hein S, Bauer EP, Schaper J. Structural correlate of atrial fibrillation in human patient. Cardiovasc Res. 2002;54:361–379
  7. Guzik TJ, West NEJ, Black E, McDonald D, Ratnatunga C, Pillai R, et al. Vascular superoxide production by NAD(P)H oxidase association with endothelial dysfunction and clinical risk factors. Cir Res. 2000;86:e86–e90
  8. Warnholtz A, Nickenig G, Schulz E, Macharzina R, Brasen JH, Skatchkov M, et al. Increased NADH-oxidase-mediated superoxide production in the early stages of atherosclerosis: evidence for involvement of the renin–angiotensin system. Circulation. 1999;99:2027–2033
  9. Rajagopalan S, Kurz S, Münzel T, Tarpey M, Freeman BA, Griendling KK, et al. Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. J Clin Invest. 1996;97:1916–1923
  10. Krijnen PAJ, Meischl C, Hack CE, Meijer CJLM, Visser CA, Roos D, et al. Increased nox2 expression in human cardiomyocytes after acute myocardial infarction. J Clin Pathol. 2003;56:194–199
  11. Ausma J, Wijffels M, Thone F, Wouters L, Allessie M, Borgers M. Structural changes of atrial myocardium due to sustained atrial fibrillation in the goat. Circulation. 1997;96:3157–3163
  12. Dimmeler S, Zeiher AM. Reactive oxygen species and vascular cell apoptosis in response to angiotensin II and pro-atherosclerotic factors. Reg Peptides. 2000;90:19–25
  13. Khaper N, Singal PK. Modulation of oxidative stress by a selective inhibition of angiotensin II type 1 receptors in MI rats. J Am Coll Cardiol. 2001;37:1461–1466
  14. Grigioni F, Enriquez-Sarano M, Ling LH, Bailey KR, Seward JB, Tajik AJ, et al. Sudden death in mitral regurgitation due to flail leaflet. J Am Coll Cardiol. 1999;34:2078–2085
  15. Bedard K, Krause KH. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev. 2007;87:245–313
  16. Griendling KK, Sorescu D, Ushio-Fukai M. NAD(P)H oxidase: role in cardiovascular biology and disease. Circ Res. 2000;86:494–501
  17. Cave A, Grieve D, Johar S, Zhang M, Shah AM. NADPH oxidase-derived reactive oxygen species in cardiac pathophysiology. Philos Trans R Soc Lond B Biol Sci. 2005;360:2327–2334
  18. Kim YM, Guzik TJ, Zhang YH, Zhang MH, Kattach H, Ratnatunga C, et al. A myocardial nox2 containing NAD(P)H oxidase contributes to oxidative stress in human atrial fibrillation. Circ Res. 2005;97:629–636
  19. Mihm MJ, Yu F, Carnes CA, Reiser PJ, McCarthy PM, Van Wagoner DR, et al. Impaired myofibrillar energetics and oxidative injury during human atrial fibrillation. Circulation. 2001;104:174–180
  20. Hare JM. Oxidative stress and apoptosis in heart failure. Circ Res. 2001;89:198–200
  21. Saavedra WF, Paolocci N, St John ME, Skaf MW, Stewart GC, Xie JS, et al. Imbalance between xanthine oxidase and nitric oxide synthase signaling pathways underlies mechanoenergetic uncoupling in the failing heart. Circ Res. 2002;90:297–304
  22. Hensley K, Robinson KA, Gabbitta SP, Salsman S, Floyd R. Reactive oxygen signaling and cell injury. Free Radic Biol Med. 2000;28:1456–1462
  23. Droge W. Free radicals in the physiological control of cell function. Physiol Rev. 2002;82:47–95
  24. Suematsu N, Tsutsui H, Wen J, Kang D, Ikeuchi M, Ide T, et al. Oxidative stress mediates tumor necrosis factor-α-induced mitochondrial DNA damage and dysfunction in cardiac myocytes. Circulation. 2003;107:1418–1423
  25. Atlante A, Calissano P, Bobba A, Azzariti A, Marra E, Passarella S. Cytochrome c is released from mitochondria in a reactive oxygen species (ROS)-dependent fashion and can operate as a ROS scavenger and as a respiratory substrate in cerebellar neurons undergoing excitotoxic death. J Biol Chem. 2000;275:37159–37166
  26. Chang JP, Chen MC, Lin WY, Liu WH, Chen CJ, Chen YL, et al. DNA repair in TUNEL-positive atrial cardiomyocytes of mitral and tricuspid valve diseases: potential mechanism for preserving cardiomyocytes. Int J Cardiol. 2009;(in press)
  27. Chen MC, Chang JP, Chang HW, Chen CJ, Yang CH, Chen YH, et al. Clinical determinants of sinus conversion by radiofrequency maze procedure for persistent atrial fibrillation in patients undergoing concomitant mitral valvular surgery. Am J Cardiol. 2005;96:1553–1557

 Disclosure: No conflict of interest exists in this study.

PII: S1054-8807(09)00157-4

doi: 10.1016/j.carpath.2009.12.005

Cardiovascular Pathology
Volume 20, Issue 2 , Pages 99-106 , March 2011