Cardiovascular Pathology
Volume 20, Issue 2 , Pages 77-83 , March 2011

The infarcted cardiac microenvironment cannot selectively promote embryonic stem cell differentiation into cardiomyocytes

  • You-Ren Chen

      Affiliations

    • Department of Cardiology, The Second Affiliated Hospital to Medical College, Shantou University, Shantou 515041, PR China
    • The two authors contributed equally to this work.
    • ,
  • Yang Li

      Affiliations

    • Stem Cell Research Center, Peking University Health Science Center, Beijing 100191, PR China
    • The two authors contributed equally to this work.
    • ,
  • Li Chen

      Affiliations

    • Center for Molecular Development and Disease, Institute of Biosciences and Technology, Texas A&M University health Science Center, Houston, TX 77030, USA
    • ,
  • Xin-Chun Yang

      Affiliations

    • Department of Cardiology, Chaoyang Hospital, Capital Medical University, Beijing 100020, PR China
    • ,
  • Pi-Xiong Su

      Affiliations

    • Department of Cardiology, Chaoyang Hospital, Capital Medical University, Beijing 100020, PR China
    • Corresponding Author InformationCorresponding authors. Department of Cardiology, Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
    • ,
  • Jun Cai

      Affiliations

    • Department of Cardiology, Chaoyang Hospital, Capital Medical University, Beijing 100020, PR China
    • Corresponding Author InformationCorresponding authors. Department of Cardiology, Chaoyang Hospital, Capital Medical University, Beijing 100020, China.

Received 16 November 2008 ,Revised 15 November 2009 ,Accepted 18 December 2009.

References 

  1. Towbin JA, Bowles NE. The failing heart. Nature. 2002;415:227–233
  2. Orlic D, Hill JM, Arai AE. Stem cells for myocardial regeneration. Circ Res. 2002;91:1092–1102
  3. Evans MJ, Kaufman MH. Establishment in culture of pluripotential cells from mouse embryos. Nature. 1981;292:154–156
  4. Thomson JA, Itskovitz-Elder J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, et al. Embryonic stem cell lines derived from human blastocysts. Science. 1998;282:1145–1147
  5. Maltsev VA, Wobus AM, Robwedel J, Bader M, Hescheler J. Cardiomyocytes differentiated in vitro from embryonic stem cells developmentally express cardiac-specific genes and ionic currents. Circ Res. 1994;75:233–244
  6. Kehat I, Dorit KK, Snir M, Segev H, Amit M, Gepstein A, et al. Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes. J Clin Invest. 2001;108:407–414
  7. Behfar A, Zingman LV, Hodgson DM, Rauzier JM, Kane GC, Terzic A, et al. Stem cell differentiation requires a paracrine pathway in the heart. FASEB J. 2002;16:1558–1566
  8. Singla DK, Hacker TA, Ma L, Douglas PS, Sullivan R, Lyons GE, et al. Transplantation of embryonic stem cells into the infarcted mouse heart: formation of multiple cell types. J Mol Cell Cardiol. 2006;40:195–200
  9. Nussbaum J, Minami E, Laflamme MA, Virag JA, Ware CB, Masino A, et al. Transplantation of undifferentiated murine embryonic stem cells in the heart: teratoma formation and immune response. FASEB J. 2007;21:1345–1357
  10. Tomescot A, Leschik J, Bellamy VE, Dubois G, Messas E, Bruneval P, et al. Differentiation in vivo of cardiac committed human embryonic stem cells in post-myocardial infarcted rats. Stem Cells. 2007;25:2200–2205
  11. Schuldiner M, Yanuka O, Itskovitz-Eldor J, Melton DA, Benvenisty N. Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells. Proc Natl Acad Sci USA. 2000;97(21):11307–11312
  12. Pfeffer MA, Braunwald E. Ventricular remodeling after myocardial infarction: experimental observations and clinical implications. Circulation. 1990;81:1161–1172
  13. Frangogiannis NG, Smith CW, Entman ML. The inflammatory response in myocardial infarction. Cardiovasc Res. 2002;53(1):31–47
  14. He Q, Trindade PT, Stumm M, Li J, Zammaretti P, Bettiol E, et al. Fate of undifferentiated mouse embryonic stem cells within the rat heart: role of myocardial infarction and immune suppression. J Cell Mol Med. 2009;13(1):188–201
  15. Stripecke R, Carmen M, Skeiton D, Satake N, Halene S, Kohn D. Immune response to green florescent protein: implications for gene therapy. Gene Ther. 1999;6:1305–1312
  16. Rosenzweig M, Connole M, Glickman R. Inductor of cytotoxic T lymphocyte and antibody responses to enhanced green florescent protein following transplantation of transduced CD 34+ hematopoietic cells. Blood. 2001;97:1951–1959
  17. Li L, Baroja M, Majumdar A, Rouleau A, Gallacher L, Ferber I, et al. Human embryonic stem cells possess immune-privileged properties. Stem Cells. 2004;22:448–456
  18. Fandrich F, Dresske B, Bader M, Schulze M. Embryonic stem cells share immune-privileged features relevant for tolerance induction. J Mol Med. 2002;80:343–350
  19. Fandrich F, Lin X, Chai GX, Schulze M, Ganten D, Bader M, et al. Preimplantation-stage stem cells induce long-term allogenic graft acceptance without supplementary host conditioning. Nat Med. 2003;8:171–178
  20. Drukkera M, Katchmanb H, Katzc G, Even-Tov Friedman S, Shezen E, Hornstein E, et al. Human embryonic stem cells and their differentiated derivatives are less susceptible to immune rejection than adult cells. Stem Cells. 2000;24:221–226
  21. Swijnenburg RJ, Tanaka TM, Vogel H, Baker J, Kofidis T, Gunawan F, et al. Embryonic stem cells immunogenicity increases upon differentiation after transplantation into ischemic myocardium. Circulation. 2005;112(Suppl):166–172
  22. Kofidis T, Jorg L, Tanaka M, Zwierzchoniewska M, Haverich A, Robbins RC. They are not stealthy in the heart: embryonic stem cells trigger cell infiltration, humoral and T-lymphocyte-based host immune response. Eur Cardiothorac Surg. 2005;28:461–466
  23. Kofidis T, Darren LR, Swijnenburg R, Greeve JM, Klima U, Robbins RC. Allopurinol/uricase and ibuprofen enhance engraftment of cardiomyocyte-enriched human embryonic stem cells and improve cardiac function following myocardial injury. Eur Cardiothorac Surg. 2006;29:50–55
  24. Drukker M, Katz G, Urbach A, Schuldiner M, Markel G, Itskovitz-Eldor J, et al. Characterization of the expression of MHC proteins in human embryonic stem cells. Proc Natl Acad Sci U S A. 2002;23(99(15)):9864–9869
  25. Swijnenburg RJ, Tanaka M, Vogel H, Baker J, Kofidis T, Gunawan F, et al. Embryonic stem cell immunogenicity increases upon differentiation after transplantation into ischemic myocardium. Circulation. 2005;112:I–166-I-172

PII: S1054-8807(09)00155-0

doi: 10.1016/j.carpath.2009.12.003

Cardiovascular Pathology
Volume 20, Issue 2 , Pages 77-83 , March 2011

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