Cardiovascular Pathology
Volume 19, Issue 3 , Pages 153-157 , May 2010

Metastatic malignant melanoma manifesting as an intracardiac mass

  • Angela Wood

      Affiliations

    • Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
  • ,
  • Svetomir N. Markovic

      Affiliations

    • Department of Oncology, Mayo Clinic, Rochester, MN, USA
    • The Melanoma Study Group, Mayo Clinic, Rochester, MN, USA
  • ,
  • Patricia J.M. Best

      Affiliations

    • Department of Cardiology, Mayo Clinic, Rochester, MN, USA
  • ,
  • Lori A. Erickson

      Affiliations

    • Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
    • The Melanoma Study Group, Mayo Clinic, Rochester, MN, USA
    • Corresponding Author InformationCorresponding author. Division of Anatomic Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Tel.: +1 507 284 1199.

Received 29 October 2008 ,Revised 9 December 2008 ,Accepted 19 December 2008.

References 

  1. Chiles C, Woodard PK, Gutierrez FR, Link KM. Metastatic involvement of the heart and pericardium: CT and MR imaging. Radiographics. 2001;21:439–449
  2. Lobo A, Lewis JF, Conti CR. Intracardiac masses detected by echocardiography: case presentations and review of the literature. Clin Cardiol. 2000;23:702–708
  3. Klatt EC, Heitz DR. Cardiac metastases. Cancer. 1990;65:1456–1459
  4. Hanfling SM. Metastatic cancer to the heart. Review of the literature and report of 127 cases. Circulation. 1960;22:474–483
  5. Bussani R, De-Giorgio F, Abbate A, Silvestri F. Cardiac metastases. J Clin Pathol. 2007;60:27–34
  6. Savoia P, Fierro MT, Zaccagna A, Bernengo MG. Metastatic melanoma of the heart. J Surg Oncol. 2000;75:203–207
  7. Sheldon R, Isaac D. Metastatic melanoma to the heart presenting with ventricular tachycardia. Chest. 1991;99:1296–1298
  8. Lustig V, Vlasveld LT, Bakker RH, Schreuder JE, Mooi WJ, ten Bokkel Huinink WW. Intracardiac metastases, report of three cases. Neth J Med. 1991;38:29–32
  9. MacGee W. Metastatic and invasive tumours involving the heart in a geriatric population: a necropsy study. Virchows Arch A Pathol Anat Histopathol. 1991;419:183–189
  10. Glancy DL, Roberts WC. The heart in malignant melanoma. A study of 70 autopsy cases. Am J Cardiol. 1968;21:555–571
  11. Abraham KP, Reddy V, Gattuso P. Neoplasms metastatic to the heart: review of 3314 consecutive autopsies. Am J Cardiovasc Pathol. 1990;3:195–198
  12. Gibbs P, Cebon JS, Calafiore P, Robinson WA. Cardiac metastases from malignant melanoma. Cancer. 1999;85:78–84
  13. Malouf JF, Thompson RC, Maples WJ, Wolfe JT. Diagnosis of right atrial metastatic melanoma by transesophageal echocardiographic-guided transvenous biopsy. Mayo Clin Proc. 1996;71:1167–1170
  14. Basarici I, Demir I, Yilmaz H, Altekin RE. Obstructive metastatic malignant melanoma of the heart: imminent pulmonary arterial occlusion caused by right ventricular metastasis with unknown origin of the primary tumor. Heart Lung. 2006;35:351–354
  15. Bossert T, van Son JA, Autschbach R, Mohr FW. Resection of a right atrial metastatic melanoma with unknown origin of primary tumor. Eur J Cardiothorac Surg. 1999;15:373–375
  16. Qu G, Kaur JS, Seward JB. Metastatic melanoma presenting as cardiac mass and hemobilia. Am J Med Sci. 2003;325:157–159
  17. Vetto JT, Heelan RT, Burt M. Malignant melanoma metastatic to the right atrium: an asymptomatic solitary metastasis diagnosed incidentally by magnetic resonance imaging. J Thorac Cardiovasc Surg. 1992;104:843–844
  18. Ozer N, Yavuz B, Atalar E. Recurrent syncope in a case of metastatic malignant melanoma–an unusual presentation of an uncommon disease. Eur J Echocardiogr. 2006;7:233–234
  19. Merer DM, Dutcher JP, Mercando A, Brodman R, Suhrland MJ, Bhandari A, et al. Case report: clinical findings and successful resection of melanoma metastatic to the right atrium. Cancer Invest. 1994;12:409–413
  20. Marti G, Galve E, Huguet J, Soler Soler J. Cardiac metastases of malignant melanoma mimicking sick sinus syndrome. Rev Esp Cardiol. 2004;57:589–591
  21. Gosalakkal JA, Sugrue DD. Malignant melanoma of the right atrium: antemortem diagnosis by transvenous biopsy. Br Heart J. 1989;62:159–160
  22. Gaudree L, Chabrun A, Corbi P, Levillain P, Herpin D. Intracardiac metastasis of malignant melanoma. Literature review and case report. Arch Mal Coeur Vaiss. 2000;93:1339–1342
  23. Chen RH, Gaos CM, Frazier OH. Complete resection of a right atrial intracavitary metastatic melanoma. Ann Thorac Surg. 1996;61:1255–1257
  24. Chrissos DN, Stougiannos PN, Mytas DZ, Katsaros AA, Andrikopoulos GK, Kallikazaros IE. Multiple cardiac metastases from a malignant melanoma. Eur J Echocardiogr. 2008;9:391–392
  25. Prabhakar G, Vasilakis A, Hill RC, Cruzzavala JL, Graeber GM, Gustafson RA, et al. Right atrial metastatic melanoma in a patient with transient ischemic attacks. Ann Thorac Surg. 1998;65:844–846
  26. Canver CC, Lajos TZ, Bernstein Z, DuBois DP, Mentzer RM. Intracavitary melanoma of the left atrium. Ann Thorac Surg. 1990;49:312–313
  27. Chello M, Marchese AR, Panza A, Mastroroberto P, Di Lello F. Primary malignant melanoma of the oesophagus with a left atrial metastasis. Thorax. 1993;48:185–186
  28. Silvestri F, Bussani R, Pavletic N, Mannone T. Metastases of the heart and pericardium. G Ital Cardiol. 1997;27:1252–1255
  29. Bryant J, Vuckovic G. Metastatic tumors of the endocardium: report of three cases. Arch Pathol Lab Med. 1978;102:206–208
  30. Hanley PC, Shub C, Seward JB, Wold LE. Intracavitary cardiac melanoma diagnosed by endomyocardial left ventricular biopsy. Chest. 1983;84:195–198
  31. Mindell SM, Chernick AW, Sugarman MH, Zirkin RM, Bloom RE. Right ventricular metastatic melanoma 27 years after resection of the primary tumor. Cancer. 1989;63:1237–1239

 No funding was received in support of our study.

PII: S1054-8807(08)00191-9

doi: 10.1016/j.carpath.2008.12.010

Cardiovascular Pathology
Volume 19, Issue 3 , Pages 153-157 , May 2010