Cardiovascular Pathology
Volume 19, Issue 2 , Pages e21-e27 , March 2010

Accumulation of mitochondrial genome variations in Persian LQTS patients: a possible risk factor?

  • Mehri Khatami

      Affiliations

    • Department of Genetics, Science School, Tarbiat Modares University (TMU), Tehran, Iran
    • ,
  • Massoud Houshmand

      Affiliations

    • Department of Medical Genetics, National Institute for Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran
    • Special Medical Center, Tehran, Iran
    • Corresponding Author InformationCorresponding author. Department of Medical Genetics, National Institute for Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran. Tel.: +98 21 44580390; fax: +98 21 44580399.
    • ,
  • Majid Sadeghizadeh

      Affiliations

    • Department of Genetics, Science School, Tarbiat Modares University (TMU), Tehran, Iran
    • ,
  • Mahmood Eftekharzadeh

      Affiliations

    • Heart Arrhythmia Center, Tehran, Iran
    • ,
  • Mohammad Mehdi Heidari

      Affiliations

    • Department of Genetics, Science School, Tarbiat Modares University (TMU), Tehran, Iran
    • ,
  • Siamak Saber

      Affiliations

    • Special Medical Center, Tehran, Iran
    • ,
  • Kambiz Banihashemi

      Affiliations

    • Special Medical Center, Tehran, Iran
    • ,
  • Barbara Scheiber-Mojdehkar

      Affiliations

    • Department of Medical Chemistry, Medical University of Vienna, Vienna, Austria

Received 2 August 2008 ,Revised 25 November 2008 ,Accepted 16 December 2008.

References 

  1. Antzelevitch C. Heterogeneity and cardiac arrhythmias; an overview. Heart Rhythm. 2007;4:964–972
  2. Vincent GM. The long QT syndrome. Indian Pacing Electrophysiol J. 2002;2:127–147
  3. Towbin JA. Molecular genetic basis of sudden cardiac death. Cardiovasc Pathol. 2001;10:283–295
  4. Wilde AM, Bezzina C. Genetics of cardiac arrhythmias. Heart. 2005;91:1352–1358
  5. Mohler PJ, Splawsk I, Napolitano C, Bottelli G, Sharpe L, Timothy K, et al. A cardiac arrhythmia syndrome caused by loss of ankyrin-B function. Proc Natl Acad Sci U S A. 2004;101:9137–9142
  6. Das B, Sarkar C. Cardiomyocyte mitochondrial KATP channels participate in the antiarrhythmic and antiinfarct effects of KATP activators during ischemia and reperfusion in an intact anesthetized rabbit model. J Pharmacol. 2003;55:771–786
  7. Priori SG. Inherited arrhythmogenic diseases, the complexity beyond monogenic disorders. Circ Res. 2004;94:140–145
  8. Mohamed SA, Hanke T, Erasmi AW, Bechtel MJF, Scharfschwerdt M, Meissner C, et al. Mitochondrial DNA deletions and the aging heart. Exp Gerontol. 2006;41:508–517
  9. Arbostini E, Diegoli M, Fasani R, Grasso M, Morbini P, Banchieri N, et al. Mitochondrial DNA mutations and mitochondrial abnormalities in dilated cardiomyopathy. Am J Pathol. 1998;153:1501–1510
  10. Bindoff L. Mitochondria and the heart. Eur Heart J. 2003;24:221–224
  11. Matsuoka R, Furutani M, Hayashi J, Isobe K, Akimoto K, Shibata T. A mitochondrial DNA mutation cosegregates with the pathophysiological U wave. Biochem Biophys Res Commun. 1999;257:228–233
  12. Arnestad M, Opdal SH, Vege A, Rgnum TO. A mitochondrial DNA polymorphism associated with cardiac arrhythmia investigated in sudden infant death syndrome. Acta Paediatr. 2007;52:1–5
  13. Opdal SH, Vege A, Egeland T, Musse MA, Rognum TO. Possible role of mtDNA mutations in sudden infant death. Pediatr Neurol. 2002;27:23–29
  14. Houshmand M, Mahmoudi T, Shafa Shariat Panahi M, Seyedena Y, Saber S, Ataei M. Identification of a new human mtDNA polymorphism (A14290) in the NADH dehydrogenase subunit 6 gene. Braz J Med Biol Res. 2006;39:725–730
  15. Kurtz A, Lueth M, Kluwe L, Zhang T, Foster R, Mautner VF, et al. Somatic mitochondrial DNA mutations in neurofibromatosis type 1-associated tumors. Mol Cancer Res. 2004;2:433–441
  16. Penta JS, Johnson FM, Wachsman T. Mitochondrial DNA in human malignancy. Mutat Res. 2001;488:119–133
  17. Wong LJC, Liang MH, Kwon H, Park J, Bai RK, Tan DJ. Comprehensive scanning of the entire mitochondrial genome for mutations. Clin Chem. 2002;48:1901–1912
  18. Ito M, Tran Le S, Chaudhari D, Higashimoto T, Maslim A, Boles RG. Screening of mitochondrial DNA heteroplasmy in children at risk for mitochondrial disease. Mitochondrion. 2001;1:269–278
  19. Anderson S, Bankier AT, Barrel BG, de Bruijin MHL, Coulson AR, Drouin J, et al. Sequence and organization of the human mitochondrial genome. Nature. 1981;290:457–465
  20. MITOMAP: a human mitochondrial genome database. Available from: http://www.mitomap.org/2008;
  21. Priori SG, Cerrone M. Molecular genetics: Is it making an impact in the management of inherited arrhythmogenic syndromes?. Hell J Cardiol. 2005;46:83–87
  22. Casademont J, Miro O. Electron transport chain defects in heart failure. Heart Fail Reviews. 2002;7:131–139
  23. Optal SH, Rognum TO. The sudden infant death syndrome gene: does it exist?. Pediatrics. 2004;114:506–512
  24. DiMauro S. Mitochondrial medicine. Biomed Biophis Acta. 2004;1659:107–114
  25. Tan DJ, Bai RK, Wong LJC. Comprehensive scanning of somatic mitochondrial DNA mutations in breast cancer. Cancer Res. 2002;62:972–976

 This research was supported by Tarbiat Modares University (TMU), Tehran, Iran.

PII: S1054-8807(08)00190-7

doi: 10.1016/j.carpath.2008.12.009

Cardiovascular Pathology
Volume 19, Issue 2 , Pages e21-e27 , March 2010

Article Tools

* Image Usage & Resolution