Cardiovascular Pathology
Volume 19, Issue 2 , Pages 112-116 , March 2010

Mechanical ventricular assistance in heart failure: pathology of the cardiac apex removed during device implantation

  • Aurélie Cazes

      Affiliations

    • Department of Pathology, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France
    • Université Paris Descartes, Paris, France
    • Corresponding Author InformationCorresponding author. Service d'Anatomie Pathologique, Hôpital Européen Georges Pompidou, 75015-Paris, France. Tel.: +33 1 56 09 38 86; fax: +33 1 56 09 38 89.
    • ,
  • Jean-Paul Duong Van Huyen

      Affiliations

    • Department of Pathology, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France
    • Université Paris Descartes, Paris, France
    • ,
  • Paul Fornes

      Affiliations

    • Department of Pathology, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France
    • Université Paris Descartes, Paris, France
    • ,
  • Catherine Amrein

      Affiliations

    • Cardiac Transplantation Unit, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France
    • ,
  • Romain Guillemain

      Affiliations

    • Cardiac Transplantation Unit, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France
    • ,
  • Jean-Michel Grinda

      Affiliations

    • Department of Cardiac Surgery, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France
    • ,
  • Patrick Bruneval

      Affiliations

    • Department of Pathology, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France
    • Université Paris Descartes, Paris, France

Received 21 June 2008 ,Revised 17 September 2008 ,Accepted 28 October 2008.

References 

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  3. Maybaum S, Stockwell P, Naka Y, Catanese K, Flannery M, Fisher P, et al. Assessment of myocardial recovery in a patient with acute myocarditis supported with a left ventricular assist device: a case report. J Heart Lung Transplant. 2003;22:202–209
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  12. Birks EJ, Tansley PD, Hardy J, George RS, Bowles CT, Burke M, et al. Left ventricular assist device and drug therapy for the reversal of heart failure. N Engl J Med. 2006;355:1873–1884
  13. McBride LR, Naunheim KS, Fiore AC, Moroney DA, Swartz MT. Clinical experience with 111 thoratec ventricular assist devices. Ann Thorac Surg. 1999;67:1233–1238discussion 1238
  14. Slaughter MS, Tsui SS, El-Banayosy A, Sun BC, Kormos RL, Mueller DK, et al. Results of a multicenter clinical trial with the Thoratec Implantable Ventricular Assist Device. J Thorac Cardiovasc Surg. 2007;133:1573–1580
  15. Rose EA, Gelijns AC, Moskowitz AJ, Heitjan DF, Stevenson LW, Dembitsky W, et al. Long-term mechanical left ventricular assistance for end-stage heart failure. N Engl J Med. 2001;345:1435–1443
  16. Rose AG, Park SJ. Pathology in patients with ventricular assist devices: a study of 21 autopsies, 24 ventricular apical core biopsies and 24 explanted hearts. Cardiovasc Pathol. 2005;14:19–23
  17. Maybaum S, Mancini D, Xydas S, Starling RC, Aaronson K, Pagani FD, et al. Cardiac improvement during mechanical circulatory support: a prospective multicenter study of the LVAD Working Group. Circulation. 2007;115:2497–2505
  18. Bruckner BA, Stetson SJ, Perez-Verdia A, Youker KA, Radovancevic B, Connelly JH, et al. Regression of fibrosis and hypertrophy in failing myocardium following mechanical circulatory support. J Heart Lung Transplant. 2001;20:457–464
  19. Milting H, Jacob M, Kassner A, Heimann P, Mannherz HG, Becker G, et al. The structural examination of myocardial samples from patients with end-stage heart failure supported by ventricular assist devices using electron microscopy and amino acid analysis reveals low degree of reverse remodeling. J Heart Lung Transplant. 2004;23:396–404
  20. Magnani JW, Dec GW. Myocarditis: current trends in diagnosis and treatment. Circulation. 2006;113:876–890
  21. Felker GM, Thompson RE, Hare JM, Hruban RH, Clemetson DE, Howard DL, et al. Underlying causes and long-term survival in patients with initially unexplained cardiomyopathy. N Engl J Med. 2000;342:1077–1084
  22. Farrar DJ, Holman WR, McBride LR, Kormos RL, Icenogle TB, Hendry PJ, et al. Long-term follow-up of Thoratec ventricular assist device bridge-to-recovery patients successfully removed from support after recovery of ventricular function. J Heart Lung Transplant. 2002;21:516–521

PII: S1054-8807(08)00159-2

doi: 10.1016/j.carpath.2008.10.013

Cardiovascular Pathology
Volume 19, Issue 2 , Pages 112-116 , March 2010

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