Cardiovascular Pathology
Volume 9, Issue 3 , Pages 161-173 , May 2000

The Histopathology of Endocardial Sclerosis

  • William E Stehbens, MD, D. Phil

      Affiliations

    • Departments of Pathology and Molecular Medicine and Obstetrics and Gynaecology, Wellington South, New Zealand
    • Corresponding Author InformationAddress for correspondence: W. E. Stehbens, MD, Department of Pathology and Molecular Medicine, Wellington School of Medicine, PO Box 7343, Wellington South, New Zealand. Tel: (64) 4-385- 5999; Fax: (64) 4-389-5725
  • ,
  • Brett Delahunt, MD

      Affiliations

    • Departments of Pathology and Molecular Medicine and Obstetrics and Gynaecology, Wellington South, New Zealand
  • ,
  • Jane M Zuccollo, MB, BCh

      Affiliations

    • Wellington School of Medicine, Wellington South, New Zealand

Received 22 February 2000 ,Revised 18 April 2000 ,Accepted 8 May 2000.

References 

  1. Stehbens WE. Atherosclerosis and degenerative diseases of blood vessels. In:  Stehbens WE,  Lie JT editor. Vascular Pathology. London: Chapman & Hall; 1995;p. 175–269
  2. Stehbens WE. The pathogenesis of atherosclerosis (a critical evaluation of the evidence). Cardiovasc Pathol. 1997;6:123–153
  3. Vikhert AM, Zhdanov VS. Role of rhythmic structures of aortic intima in the development of atherosclerosis. Zentralbl allg Pathol Pathol Anat. 1989;135:607–617
  4. Smith EB, Slater R. Lipids and lipoproteins in ageing aortic intima. Proc Roy Soc Med. 1972;65:675–677
  5. Young AH, Robinson A, Brash JC. Blood, vascular and lymphatic systems. In: Cunningham's Text-Book of Anatomy. Brash JC, Jamieson EB, eds. 8th Ed. London: Oxford University Press, 1943:1192.
  6. Maximov AA, Bloom W. A Textbook of Histology. 4th Ed. Philadelphia: WB Saunders Co; 1944;
  7. Weiss L, Greep PO. In: Histology. 4th Ed. New York: McGraw-Hill; 1977;p. 420–423
  8. Ham AW, Cormack DH. Histology. 8th Ed. Philadelphia: JB Lippincott Co; 1974;
  9. Copenhaver WM, Kelly DE, Wood RL. Bailey's Textbook of Histology. 17th Ed. Baltimore: Williams & Wilkins Co; 1978;
  10. Leeson CR, Leeson TS, Paparo AA. In: Textbook of Histology. 8th Ed. Philadelphia: WB Saunders Co; 1988;p. 255–256
  11. Junqueira LC, Carneiro J, Kelley RO. Basic Histology. 6th Ed. Norwalk, Connecticut: Appleton & Lange; 1989;
  12. Wheater PR, Burkitt HG. Functional Histology. A Text and Colour Atlas. 2nd. Ed. Edinburgh: Churchill Livingstone, 1987:119.
  13. Ferrans VJ. Mural endocardium. In: Cardiovascular Pathology. Silver MD, ed. Vol. 1, New York: Churchill Livingstone, 1991:82–84.
  14. Ball JD, Williams AW, Davies JNP. Endomyocardial fibrosis. Lancet. 1954;i:1049–1054
  15. Davies JNP. Some considerations regarding obscure diseases affecting the mural endocardium. Am Heart J. 1960;59:600–631
  16. Davies JNP. Ball JD. The pathology of endomyocardial fibrosis in Uganda. Br Heart J. 1955;17:337–359
  17. Hudson REB. Cardiovascular Pathology. Vol. 1, London: Edward Arnold, 1965:863–886.
  18. Cotran RS, Kumar V, Robbins RL. In: Robbins Pathologic Basis of Disease. 4th Ed. Philadelphia: WB Saunders Co; 1989;p. 646–647
  19. Roberts WC, Levy RI, Fredrickson DS. Hyperlipoproteinemia. A review of five types with first report of necropsy findings in type 3. Arch Pathol 1970;90:46–56.
  20. Roberts WC, Ferrans VJ, Levy RI, Fredrickson DS. Cardiovascular pathology in hyperlipoproteinemia. Anatomic observations in 42 necropsy patients with normal or abnormal serum lipoprotein patterns. Am J Cardiol 1973;31:557–570.
  21. Caplan H. A case of endocardial fibro-elastosis with features of glycogen-storage disease. J Pathol Bacteriol. 1958;76:77–82
  22. Dangel JH. Cardiovascular changes in children with mucopolysaccharide storage diseases and related disorders — clinical and echocardiographic findings in 64 patients. Europ J Pediatr. 1998;157:534–538
  23. Dincsoy MY, Dincsoy HP, Kessler AD, Jackson MA, Sidbury JB. Generalized glycogenosis and associated fibroelastosis. J Pediatrics. 1965;67:728–740
  24. Stehbens WE, Wierzbicki E. The relationship of hypercholesterolemia to atherosclerosis with particular emphasis on familial hypercholesterolemia, diabetes mellitus, obstructive jaundice, myxedema and the nephrotic syndrome. Progr Cardiovasc Dis. 1988;30:289–306
  25. Anderson JR. Muir's Textbook of Pathology. 12th Ed. London: Edward Arnold, 1985:15.17–15.18.
  26. Hudson REB. In: Cardiovascular Pathology. Vol. 3. London: Edward Arnold; 1970;p. 520–527
  27. Westwood M, Harris R, Burn JL, Barson AJ. Heredity in primary endocardial fibroelastosis. Br Heart J. 1975;37:1077–1084
  28. Factor SM. Endocardial fibroelastosis (myocardial and vascular alterations associated with viral-like nuclear particles). Am Heart J. 1978;96:781–801
  29. Ni J, Bowles NE, Kim Y-H, et al.  Viral infection of the myocardium in endocardial fibroelastosis. Molecular evidence for the role of mumps virus as an etiologic agent. Circulation. 1997;95:133–139
  30. Anderson DH, Kelly J. Endocardial fibro-elastosis 1. Endocardial fibro-elastosis with congenital malformations of the heart. Pediatrics. 1956;18:513–538
  31. Pomerance A. Ageing changes in human heart valves. Br Heart J. 1967;29:222–231
  32. McMillan JB, Lev M. The aging heart. II. The valves. J Gerontol. 1964;19:1–14
  33. Davies MJ. Pathology of Cardiac Valves. London: Butterworths; 1980;
  34. Magarey FR. Pathogenesis of mitral stenosis. Br Med J. 1951;1:856–858
  35. Still WJS, Boult EH. Pathogenesis of endocardial fibro-elastosis. Lancet. 1956;2:117–118
  36. Hellwig CA. Atheromatosis of the mitral valve. Am Heart J. 1942;24:41–49
  37. Roberts WC, Buja LM. The frequency and significance of coronary arterial thrombi and other observations in fatal acute myocardial infarction. Am J Med. 1972;52:425–443
  38. Pomerance A. Pathological and clinical study of calcification of the mitral valve ring. J Clin Pathol. 1970;23:354–361
  39. Isotalo PA, Walley VM. Coronary artery erosion and dissection (an unusual complication of mitral annular calcification). Cardiovasc Pathol. 1999;8:141–145
  40. Kronzon I, Winer HE, Cohen ML. Sterile, caseous mitral annular abscess. J Am Coll Cardiol. 1983;2:186–190
  41. Roberts WC. Ninety-three hearts ⩾90 years of age. Am J Cardiol. 1993;71:599–602
  42. Kim KM, Huang S-N. Ultrastructural study of calcification of human aortic valves. Lab Invest. 1971;25:357–366
  43. Kim KM, Valigorsky JM, Mergner WJ, Jones RT, Pendergrass RF, Trump BF. Aging changes in the human aortic valve in relation to dystrophic calcification. Human Pathol. 1976;7:47–60
  44. Roberts WC, Perloff JK. Mitral valvular disease. A clinicopathologic survey of the conditions causing mitral valve to function abnormally. Ann Int Med. 1972;77:939–975
  45. Roberts WC. The senile cardiac calcification syndrome. Am J Cardiol. 1986;58:572–573
  46. Adler Y, Koren A, Fink N, et al.  Association between annulus calcification and carotid atherosclerotic disease. Stroke. 1998;29:1833–1837
  47. Adler Y, Shohat-Zabarski R, Vaturi M, et al.  Association between mitral annular calcium and aortic atheroma as detected by transesophageal cardiographic study. Am J Cardiol. 1998;81:784–786
  48. Boon A, Cherien E, Lodder S, Kessels F. Cardiac valve calcification (characteristics of patients with calcification of the mitral annulus or aortic valve). Heart. 1997;78:472–474
  49. Fulkerson PK, Beaver BM, Auseon JC, Graber HL. Calcification of the mitral annulus. Am J Med. 1979;66:967–977
  50. Nestico PF, Depace NL, Morganroth J, Kotler MN, Ross J. Mitral annular calcification (clinical, pathophysiology, and echocardiographic review). Am Heart J. 1984;107:989–996
  51. Pomerance A. Pathology of the heart in the tenth decade. J Clin Pathol. 1968;21:317–321
  52. Pomerance A. Age-related cardiovascular changes and mechanically induced endocardial pathology. In:  Silver MD editors. Cardiovascular Pathology. 2nd Ed. New York: Churchill Livingstone; 1991;p. 155–194
  53. Karsner HT. The pathology of endocarditis. JAMA. 1931;96:411–417
  54. Stehbens WE, Sonnenwirth AC, Kotrba C. Microcirculatory changes in experimental bacteremia. Exp Mol Pathol. 1969;10:295–311
  55. Stehbens WE, Kostianovsky M, Sonnenwirth AC, Kotrba C. Ultrastructure of the pulmonary microcirculation in experimental streptococcal bacteremia. Quart J Exp Physiol. 1969;54:432–441
  56. Magarey FR. On the mode of Lambl's excrescences and their relation to chronic thickening of the mitral valve. J Pathol Bacteriol. 1949;61:203–208
  57. Wauchope GM. The clinical importance of variations in the number of cusps forming the aortic and pulmonary valves. Quart J Med. 1927;21:383–399
  58. Sell S, Scully RE. Aging changes in the aortic and mitral valves. Am J Pathol. 1965;46:345–365
  59. Black-Schaffer B. Infantile endocardial fibroelastosis. Arch Pathol. 1957;63:281–306
  60. McManus JFA, Lupton CH. Lipid deposits in the aortic cusp of the mitral valve. Arch Pathol. 1963;75:674–685
  61. Dyson BC, Decker JP. Endocardial fibroelastosis in the adult. Arch Pathol. 1958;66:190–203
  62. Silver MD. Late complications of prosthetic heart valves. Arch Pathol Lab Med. 1978;102:281–284
  63. Gowing NFC. Congenital fibro-elastosis of the endocardium. J Pathol Bacteriol. 1953;65:13–28
  64. Stehbens WE. Structural and architectural changes during arterial development and the role of hemodynamics. Acta Anat. 1996;157:261–274
  65. Kausch HH. In: Polymer Fracture. 2nd Ed. Berlin: Springer-Verlag; 1987;p. 141–142,187194.
  66. Caro CG, Pedley TJ, Schroter RC, Seed WA. The Mechanics of the Circulation. Oxford: Oxford Univ. Press; 1978;
  67. Stein PD, Sabbah HN. Turbulent blood flow in the ascending aorta of humans with normal and diseased aortic valves. Cir Res. 1976;39:58–65
  68. Stein PD, Sabbah HN, Anbe DT. Comparison of disturbances of flow — in the main pulmonary artery and ascending aorta of man. Biorheology. 1979;16:357–362
  69. Nichols WW, O'Rourke MF, Hartley C. McDonald's Blood Flow in Arteries. 4th Ed. London: Arnold; 1998;
  70. Heath D, Edwards JE, Smith LA. The rheologic significance of medial necrosis and dissecting aneurysm of the ascending aorta in association with calcific aortic stenosis. Proc Staff Meet Mayo Clin. 1958;33:228–234
  71. Edwards WD, Leaf DS, Edwards JE. Dissecting aortic aneurysm associated with congenital bicuspid aortic valve. Circulation. 1978;57:1022–1025
  72. Fisher ER, Davis ER. Observations concerning the pathogenesis of endocardial thickening in the adult heart. Am Heart J. 1958;56:553–561
  73. Hudson REB. Cardiovascular Pathology. Vols. 1,2, London: Arnold, 1965.
  74. Hudson REB. Cardiovascular Pathology. Vol. 3, London: Arnold, 1970.
  75. Silver MD. (Ed.),Cardiovascular Pathology. 2nd Ed. New York: Churchill Livingstone, 1991.

PII: S1054-8807(00)00037-5

Cardiovascular Pathology
Volume 9, Issue 3 , Pages 161-173 , May 2000